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HSP90AA1 — JAK2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Plo et al., Blood 2008
(Myeloproliferative Disorders...) :
Moreover,
JAK2 activation
increased centrosome and ploidy abnormalities
Perotti et al., Breast Cancer Res 2008
(Breast Neoplasms) :
In addition to identifying new prolactin regulated genes in breast cancer cells, we found that
prolactin-JAK2-STAT5 induces expression of the
HSP90A gene, which encodes the master chaperone of cancer
Schoof et al., Cell communication and signaling : CCS 2009
:
HSP90 is
essential for
Jak-STAT signaling in classical Hodgkin lymphoma cells
Weigert et al., J Exp Med 2012
(Leukemia, B-Cell...) :
Thus,
HSP90 is a promising therapeutic
target in JAK2-driven cancers, including those with genetic resistance to
JAK enzymatic inhibitors