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HGF — SMAD2
Text-mined interactions from Literome
Yang et al., Am J Pathol 2003
(Fibrosis) :
To decipher the mechanism underlying HGF antagonizing TGF-beta1 's action, we examined the
effects of
HGF on TGF-beta1 mediated
Smad signaling ...
HGF neither
inhibited Smad-2/3 phosphorylation and their association with Smad-4 induced by TGF-beta1, nor significantly affected inhibitory Smad-6 and -7 expression and cellular abundance of Smad transcriptional co-repressors in NRK-49F cells ... In vivo,
HGF selectively
blocked Smad-2/3 nuclear accumulation in renal interstitial cells in the fibrotic kidneys induced by unilateral ureteral obstruction
Dai et al., J Am Soc Nephrol 2004
:
HGF did not
affect TGF-beta1 mediated
Smad2 phosphorylation and its nuclear translocation
Liu et al., American journal of physiology. Renal physiology 2004
(Disease Progression...) :
In interstitial fibroblasts,
HGF blocks activated
Smad-2/3 nuclear translocation, whereas it specifically upregulates the expression of the Smad transcriptional corepressor SnoN in tubular epithelial cells
Yang et al., J Am Soc Nephrol 2005
(Fibrosis...) :
However,
HGF neither
affected TGF-beta1 induced
Smad-2 phosphorylation and its subsequent nuclear translocation nor influenced the expression of inhibitory Smad-6 and -7 in tubular epithelial cells ... In vivo,
HGF did not
affect Smad-2 activation and its nuclear accumulation in tubular epithelium, but it restored SnoN protein abundance in the fibrotic kidney in obstructive nephropathy
Hoot et al., J Clin Invest 2010
(Carcinoma, Squamous Cell...) :
Smad2 loss
caused increased binding of Smad4 and CBP/p300 to the
Hgf promoter ... We therefore conclude that
Smad2 loss
causes HGF upregulation via loss of Smad2 mediated transcriptional repression and enhanced Smad3/4 mediated transactivation
de Caestecker et al., Genes Dev 1998
:
We demonstrate here that
HGF and EGF, which signal through RTKs, can also mediate SMAD dependent reporter gene activation and
induce rapid phosphorylation of endogenous
SMAD proteins by kinase ( s ) downstream of MEK1 ...
HGF induces phosphorylation and nuclear translocation of epitope tagged
Smad2 and a mutation that blocks TGF-beta signaling also blocks HGF signal transduction