Gene interactions and pathways from curated databases and text-mining

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HGF — PBK

Text-mined interactions from Literome

Duan et al., Exp Cell Res 2004 : Either Ly294002 or PD98059, specific inhibitor of the PI3K and ERK/MAPK pathways, respectively, blocked the HGF induced activation of SPK
Duan et al., Cell Signal 2006 : Here we report that Shp-2 is required for the HGF induced activation of sphingosine kinase-1 (SPK1) , a highly conserved lipid kinase that plays an important role in cell migration ... These studies suggest that Shp-2 is an SPK1 interacting protein and that it plays an indispensable role in HGF induced SPK1 activation
Duan et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2005 : HGF stimulation could increase the activity of SPK and cellular S1P in ECV304 cells