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GAB2 — PLCG2

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: GAB2 → PLCG2 (protein-protein, binding/association)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PLCG2 — GAB2 (physical association, affinity chromatography technology) Boudot et al., Cell Signal 2002*
• IRef Hprd Interaction: GAB2 — PLCG2 (in vitro) Boudot et al., Cell Signal 2002*
• IRef Hprd Interaction: GAB2 — PLCG2 (in vivo) Boudot et al., Cell Signal 2002*
• IRef Ophid Interaction: PLCG2 — GAB2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: PLCG2 — GAB2 (aggregation, confirmational text mining) Boudot et al., Cell Signal 2002*

Text-mined interactions from Literome

Boudot et al., Cell Signal 2002 : LY294002 cell preincubation did not affect GAB2 , SHC and SHP2 tyrosine phosphorylation but inhibited the binding of PLC-gamma2 to GAB2 and SHP2
Mao et al., J Clin Invest 2006 : Interestingly, we found that in osteoclasts, PLCgamma2 formed a complex with the regulatory adapter molecule GAB2, was required for GAB2 phosphorylation, and modulated GAB2 recruitment to RANK