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CRKL — FCGR1A

Pathways - manually collected, often from reviews:

• KEGG Fc gamma R-mediated phagocytosis: FCGR1A → CRK/CRKL (protein-protein, binding/association)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CRKL — FCGR1A (physical association, affinity chromatography technology) Kyono et al., J Immunol 1998*
• IRef Hprd Interaction: CRKL — FCGR1A (in vivo) Kyono et al., J Immunol 1998*
• IRef Ophid Interaction: CRKL — FCGR1A (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Erdreich-Epstein et al., J Leukoc Biol 1999 : PP1, a specific inhibitor of Src kinases, inhibited the Fc gammaRI induced respiratory burst, as well as the tyrosine phosphorylation of Cbl and its inducible association with CrkL
Kyono et al., J Immunol 1998 : Fc gamma RI cross linking of U937IF cells results in the tyrosine phosphorylation of Cbl, Crkl , and Hef-1, an increase in the association of Crkl with Cbl via direct SH2 domain interaction and increased Crkl-Hef-1 binding