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BMP2 — UGCG
Text-mined interactions from Literome
Pierre et al., J Mol Endocrinol 2004
:
As expected,
BMP-4 induced phosphorylation and transcriptional activity of Smad1 in ovine
GCs
Luppen et al., Growth Factors 2008
:
We found that
GCs inhibited
Bmp2 via a domain > 50 kb downstream of the coding sequence ... Bmp expression was evaluated by RT-PCR ; whereas
GCs strongly
inhibited Bmp2 , Bmp4 was abundantly expressed and resistant to GCs ... In conclusion,
GCs regulate
Bmp2 via a far-downstream domain, and activation of Smad, not ALP, best predicts the pro-mineralization potential of rhBMPs