Gene interactions and pathways from curated databases and text-mining

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BMP2 — UGCG

Text-mined interactions from Literome

Pierre et al., J Mol Endocrinol 2004 : As expected, BMP-4 induced phosphorylation and transcriptional activity of Smad1 in ovine GCs
Luppen et al., Growth Factors 2008 : We found that GCs inhibited Bmp2 via a domain > 50 kb downstream of the coding sequence ... Bmp expression was evaluated by RT-PCR ; whereas GCs strongly inhibited Bmp2 , Bmp4 was abundantly expressed and resistant to GCs ... In conclusion, GCs regulate Bmp2 via a far-downstream domain, and activation of Smad, not ALP, best predicts the pro-mineralization potential of rhBMPs