◀ Back to BMP2

BMP2 — RELA

Text-mined interactions from Literome

Feng et al., J Biol Chem 2003 : NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro ... Here we have used both in vitro and in vivo approaches to demonstrate that transcription factor, NF-kappaB , regulates BMP-2 gene expression in chondrocytes ... Thus, NF-kappaB may positively regulate BMP-2 gene transcription ... Therefore, in postnatal growth plate chondrocytes, expression of BMP-2 is regulated by NF-kappaB , which may play an important role in chondrogenesis
Eliseev et al., Exp Cell Res 2006 (Bone Neoplasms...) : Here, we show that in osteosarcoma Saos2 osteoblasts, NFkappaB regulates the activity of the BMP/Smad signaling ... We therefore conclude that in osteosarcoma Saos2 cells, NFkappaB represses BMP/Smad signaling and BMP2 induced differentiation through Smad7
Sugimori et al., J Bone Miner Metab 2005 : We investigated the involvement of phosphatidylinositol 3-kinase (PI3K)/Akt mediated NF-kappaB activation by BMP-2 stimulation in the modulation of this antiapoptotic process in a chondrocytic cell line, N1511 ... Thus, BMP-2 induced NF-kappaB activation is mediated by PI3K/Akt signaling
Ghosh-Choudhury et al., J Biol Chem 2006 : BMP-2 stimulates receptor activator of NF-kappaB ligand expression
Tintut et al., J Investig Med 2006 (Atherosclerosis...) : Binding of RANKL to its cognate receptor RANK induces NF-kappaB signaling, which stimulates osteoclastic differentiation in preosteoclasts and induces bone morphogenetic protein ( BMP-2 ) expression in chondrocytes
Zhang et al., Vasc Med 2008 : Our findings indicate that Ang II-induced BMP-2 expression might contribute to NF-kappaB activation
Graham et al., Prostate 2009 (Neoplasm Metastasis...) : PI3K/Akt dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells ... In this study, we investigated whether the nuclear transcription factor NF-kappaB , implicated in PC metastasis, is involved in transcriptional regulation and activation of BMP-2 or BMP-4/Smad signaling in PC cells ... Selective inhibition of PI3K/Akt suppressed the NF-kappaB induced BMP-2 promoter activity ... Notably, the activation of BMPRII by BMP-2 is required for modulation of Smad activation by NF-kappaB in PC cells ... Based on ChIP analysis, the transcriptional regulation of BMP-2 gene by NF-kappaB may be partially attributed to binding to kappab site on the BMP-2 promoter
Hess et al., Bone 2009 : The IKK2/NF-kappaB induced BMP-2 up-regulation results in the enhancement of RUNX2 and Osterix expression, two critical regulators of the osteogenic differentiation program
Graham et al., Cancer Sci 2010 (Neoplasm Metastasis...) : We recently reported that phosphoinositide 3-kinase (PI3K)/protein kinase B ( Akt ) mediates transcriptional regulation and activation of bone morphogenetic protein (BMP)-2 signaling by nuclear factor (NF)-kappaB in bone metastatic prostate cancer cells
Mohan et al., Invest Ophthalmol Vis Sci 1998 : BMP2 and BMP4 stimulated activation of NF-kappaB ... Actinomycin D and SN50 peptide, but not SN50M control peptide, inhibited NF-kappaB activation in response to BMP2 or BMP4