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BMP2 — PRG4

Text-mined interactions from Literome

van Susante et al., J Orthop Res 2000 : Recombinant human bone morphogenetic protein-2 stimulated proteoglycan synthesis significantly only in the absence of fetal calf serum or in the presence of small amounts of the serum
van der Kraan et al., Osteoarthritis Cartilage 2000 (Arthritis, Experimental) : Role of nitric oxide in the inhibition of BMP-2 mediated stimulation of proteoglycan synthesis in articular cartilage ... Bone morphogenetic protein-2 (BMP-2) mediated stimulation of articular cartilage proteoglycan ( PG ) synthesis is suppressed in arthritic murine knee joints and by interleukin-1 (IL-1) ... BMP-2 potently stimulated proteoglycan synthesis in articular cartilage of normal knees ( up to 4-fold ) but not in arthritic knees
Li et al., J Orthop Sci 2003 : The effects of bone morphogenetic protein 2 (BMP-2) and cartilage derived morphogenetic protein 2 ( CDMP-2 ) ( singly and jointly ) on proteoglycan synthesis by a chondrocytic cell line ( MC615 ) were studied ... Both BMP-2 and CDMP-2 significantly enhanced proteoglycan production and aggrecan mRNA expression in a dose dependent manner, although BMP-2 is more effective than CDMP-2 in increasing sulfated proteoglycan production
Hills et al., J Orthop Res 2005 : BMP-2 also lead to a 7-8-fold increase in proteoglycan synthesis at the highest concentration tested, and was able to induce collagen synthesis 6.4-fold, but at a concentration of 1000 ng/mL
Gutierrez et al., J Cell Physiol 2006 : These results are the first biochemical evidence and analysis for the effect of BMP-2 on the synthesis of proteoglycan during osteogenic conversion of myoblasts and suggest a role for decorin in cell response to BMP-2
Vogt et al., Biomaterials 2008 : BMP2 led to an increase in proteoglycan and alkaline phosphatase production
Vogt et al., Biomaterials 2009 (Disease Models, Animal) : BMP2 increased Col2 expression, proteoglycan production and cell size in vitro
Kim et al., Spine (Phila Pa 1976) 2009 (Intervertebral Disc Displacement) : To demonstrate the differential effect of BMP-2 on DNA synthesis, proteoglycan synthesis, and osteocalcin mRNA expression in human IVD cells from the NP, TZ, and AF, respectively ... Only cells from the NP showed a significant increase in newly synthesized proteoglycan in response to BMP-2 ... BMP-2 clearly exerted a mitogenic effect on AF cells, and stimulated proteoglycan synthesis in NP cells
Decarlo et al., BMC biotechnology 2012 : Perlecan domain 1 recombinant proteoglycan augments BMP-2 activity and osteogenesis
Glansbeek et al., Arthritis Rheum 1997 : Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content ... To study the effect of bone morphogenetic protein 2 (BMP-2) on articular cartilage proteoglycan ( PG ) synthesis in vivo and to investigate whether BMP-2 is able to counteract the effects of interleukin-1 (IL-1) on articular cartilage PG synthesis and content