Gene interactions and pathways from curated databases and text-mining

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CRP — IL2

Text-mined interactions from Literome

Haider et al., Clin Exp Immunol 2006 (Endotoxemia) : LPS, interleukin (IL)-1 , IL-6 and tumour necrosis factor (TNF)-alpha increased and IL-10 reduced CRP expression in PBMC
Peroś-Golubicić et al., Acta Med Iugosl 1991 (Lung Diseases...) : It is well known that interleukin-1 , among other functions, stimulates the hepatic production of C-reactive protein
Mier et al., Blood 1990 : The concurrent administration of dexamethasone also prevented the IL-2 induced increase in serum levels of C-reactive protein , a hepatic acute phase reactant whose synthesis is regulated by proinflammatory cytokines such as TNF
Mackiewicz et al., Biochem J 1988 : While both interleukin-1 and tumour necrosis factor regulate biosynthesis of a number of these acute phase proteins in rabbit primary hepatocyte cultures, neither of these monokines induced C-reactive protein synthesis
Nazarov et al., Vestn Ross Akad Med Nauk 1993 : There is evidence that native pentameric C-reactive protein (CRP) and its nonmitogenic monomeric subunits compete with IL 2 at the level of lymphocyte proliferation triggering and block IL 2 receptors due to structural and antigenic similarities between CRP and IL 2
Zhang et al., Biochem J 1995 : The effect of interleukin-1 on C-reactive protein expression in Hep3B cells is exerted at the transcriptional level