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NOS2 — STAT3
Text-mined interactions from Literome
Yu et al., J Biol Chem 2003
:
JAK2/STAT3 , not ERK1/2,
mediates interleukin-6 induced activation of inducible
nitric-oxide synthase and decrease in contractility of adult ventricular myocytes
Hierholzer et al., Am J Physiol Gastrointest Liver Physiol 2004
(Enteritis...) :
Selective
iNOS inhibition in shocked animals
reduced the binding activity of NF-kappaB and
Stat3 and reduced mRNA levels of ICAM-1, IL-6, and G-CSF
Yu et al., J Biol Chem 2004
:
Flagellin induced expression of inducible
nitric-oxide synthase but not IL-6, was abolished by blocking STAT activation with AG490, and was
reduced by blocking
STAT-3 activation with anti-IL-6
Saura et al., J Biol Chem 2006
:
Stat3 mediates interleukin-6 [ correction of interelukin-6 ] inhibition of human endothelial
nitric-oxide synthase expression
Ma et al., Int J Cancer 2008
(Carcinoma...) :
These data suggest that nuclear accumulation of EGFR and
STAT3 activation by IL-6
play the key role in
iNOS expression and resultant DNA damage, leading to EBV mediated NPC
Kim et al., Free Radic Biol Med 2008
:
The inhibition of STAT1 and STAT3 by EP prevented their translocation to the nucleus and consequently
inhibited expression of
iNOS and COX-2 by inhibiting STAT1- and
STAT3 mediated transcriptional activity, followed by changes in chromatin conformation via deacetylation of histones H3 and H4 in both gene promoters
Park et al., Cytokine 2008
:
We also found that downregulation of
STAT3 using STAT3 siRNA
resulted in suppression of the NO synthesis and
iNOS expression
Broadbelt et al., American journal of physiology. Renal physiology 2009
(Ureteral Obstruction) :
These data indicate that EGFR, NFkappaB, and
STAT3 are
required for human
iNOS gene induction in response to pressure or EGF, indicating a similar mechanism of activation
Hao et al., Int J Radiat Biol 2010
:
P6, a JAK inhibitor, reduced induction of
iNOS and TNF-alpha, nuclear factor binding activity, and
activation of
STAT3 in EMF stimulated microglia
Youn et al., Nutr Cancer 2009
(Colitis...) :
Oral administration of resveratrol or piceatannol ( 10 mg/kg body weight each ) for 7 constitutive days attenuated the DSS induced inflammatory injury, upregulation of
iNOS expression, and
activation of NF-kappaB,
STAT3 , and ERK
Kou et al., Int Immunopharmacol 2011
:
The inhibitions of STAT1 and
STAT 3 by arctigenin prevented their translocation to the nucleus and consequently
inhibited expression of
iNOS , thereby suppressing the expression of inflammation associated genes, such as IL-1ß, IL-6 and MCP-1, whose promoters contain STAT binding elements
Puram et al., J Neurosci 2012
(Cell Transformation, Neoplastic...) :
Endogenous
STAT3 occupies the endogenous iNOS promoter and
stimulates iNOS transcription in EGFRvIII expressing astrocytes ... STAT3 does not appear to control iNOS transcription in astrocytes deficient in the major glioblastoma tumor suppressor protein phosphatase and tensin homolog (PTEN), suggesting that
STAT3 regulates
iNOS transcription specifically in EGFRvIII expressing astrocytes
Qi et al., Inflamm Res 2013
:
Baicalein suppressed the nuclear translocation of STAT1 and
STAT3 and
inhibited production of
iNOS upon LPS-stimulation, resulting in the inhibition of releases of NO and pro-inflammatory cytokines such as IL-1ß, IL-6, and TNF-a, in a dose dependent manner