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MAPK6 — PPARA
Text-mined interactions from Literome
Gardner et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
However, the mechanism for
PPAR ligand
dependent MAPK activation is unclear
Aouadi et al., Diabetes 2006
:
Finally, either inhibition or disruption of
p38MAPK increased peroxisome proliferator activated receptor (
PPAR)gamma expression and transactivation
Ding et al., Acta Pharmacol Sin 2007
:
Taken together, these results showed a close association between PPAR alpha and cardiomyocyte differentiation in vitro, and p38
MAPK was partly
responsible for the regulation of
PPAR alpha
Diradourian et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
Involvement of ZIP/p62 in the
regulation of
PPARalpha transcriptional activity by
p38-MAPK ... In this study we examined the
effect of
p38-MAPK on
PPARalpha transcriptional activity
Martínez de Ubago et al., Biochim Biophys Acta 2009
(Carcinoma, Hepatocellular...) :
Activation of
PPAR-alpha by the pharmacological agonist WY14643 in HTC hepatoma cells is sufficient to inhibit insulin signalling and this effect is also
dependent on p38
MAPK but not JNK kinase ... In summary, OEA inhibits insulin metabolic and mitogenic signalling by
activation of JNK and p38
MAPK via
PPAR-alpha
Yang et al., Eur J Pharmacol 2010
(MAP Kinase Signaling System...) :
Specific inhibitors of the mitogen activated protein kinases (
MAPK ) p38 ( SB203580 ) and c-Jun N-terminal kinase ( SP600125 ), but not of extracellular signal regulated kinase ( PD98059 ),
prevented AGEs induced downregulation of
PPAR? expression
Wang et al., PPAR research 2012
:
Leptin treatment also leads to a mild downregulation of PPAR mRNA expression and a significant
MAPK/ERK dependent
PPAR? phosphorylation at serine 112/82
Liu et al., Biomaterials 2013
(Brain Ischemia) :
Furthermore, CBSA-PEG-TIIA-NPs significantly decreased the mRNA expressions of iNOS and p38MAPK, upregulated
PPAR? expression, and
inhibited the protein levels of iNOS, GFAP and
p38MAPK phosphorylation