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CKM — TP53

Text-mined interactions from Literome

Jackson et al., Gene Expr 1995 : p53 dependent activation of the mouse MCK gene promoter : identification of a novel p53-responsive sequence and evidence for cooperation between distinct p53 binding sites
Zhao et al., Mol Cell Biol 1994 : Conversely, mouse wild-type p53 strongly activated the rat CKM promoter in CV-1 cells but not in HeLa cells, suggesting that, in CV-1 cells, p53 may associate with a required coactivator or is modified in a manner necessary for CKM activation
Sehgal et al., Oncogene 1993 : In HeLa cells, although wt p53 activated p50-2 but repressed the MCK and IL-6 promoters, p53 Val135 activated all three reporters
Zhao et al., Oncogene 1996 : In this report, we employed the gel-shift assay and demonstrated that recombinant, immunoaffinity purified mouse p53wt binds to this 112 bp CKM sequence and activates the in vitro transcription of the proximal CKM promoter by nuclear extracts from CV-1 cells ... The results are discussed in relation to the possible role of p53wt in the expression of CKM in cell types which may not express the myogenic transcription factors
Jackson et al., Oncogene 1998 : Synergistic transcriptional activation of the MCK promoter by p53 : tetramers link separated DNA response elements by DNA looping
Tamir et al., Oncogene 1998 : In this study we tested the involvement of p53 in the activation of MCK transcription during muscle differentiation of C2 cells ... The expression of a dominant negative p53 protein in muscle cells reduced the expression of endogenous MCK gene