Gene interactions and pathways from curated databases and text-mining

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SMPD2 — TNF

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Kreder et al., EMBO J 1999 : An essential role of FAN in the TNF induced activation of N-SMase was demonstrated using thymocytes from FAN knockout mice
Hildt et al., J Exp Med 1999 : Inhibition of the TNFR-I/FAN ( factor associated with neutral sphingomyelinase ) interaction, which is essential for TNF-alpha dependent activation of the neutral sphingomyelinase , either by cell-permeable peptides or by deletion of the FAN binding domain, prevents activation of c-Raf-1 kinase
Chatterjee et al., Chem Phys Lipids 1999 : A further role of ceramide and N-SMase in atherosclerosis was uncovered by the finding that Ox-LDL and TNF-alpha stimulated N-SMase activity ... In contrast to these observations in human hepatocytes, TNF-alpha mediated N-SMase activation did not induce apoptosis
Luberto et al., J Biol Chem 2002 : The compound was then evaluated for its ability to inhibit tumor necrosis factor (TNF) induced activation of neutral SMase (N-SMase) in MCF7 cells
Tcherkasowa et al., J Immunol 2002 : Furthermore, activation of N-SMase by TNF was strongly enhanced when RACK1, FAN, and a noncytotoxic TNF-R55 mutant were expressed concurrently, suggesting RACK1 as a modulator of N-SMase activation
Barsacchi et al., Mol Pharmacol 2003 : Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha : a novel pathway involving sequential activation of neutral sphingomyelinase , phosphatidylinositol-3 ' kinase, and Akt ... The novel pathway of activation of eNOS described here may have broad biological relevance because neutral sphingomyelinase is activated not only by TNF-alpha but also by a variety of other physiological and pathological stimuli
Testai et al., J Neurosci Res 2004 (Oligodendroglioma) : Both staurosporine and tumor necrosis factor-alpha (TNF-alpha) induced apoptosis and activated NSMase in a multiphasic manner in both OPC and HOG cells
Cailleret et al., Circulation 2004 : In cardiomyocytes obtained from control rats, 25 ng/mL TNF-alpha increased reactive oxygen species generation and N-SMase activity ( 500 % and 34 % over basal, respectively ) and decreased the amplitude of [ Ca ( 2+ ) ] ( i ) in response to electrical stimulation ( 22 % below basal )
Zeng et al., J Neurochem 2005 (Infection) : Abeta, TNF-alpha , or the combination of both, increased neutral sphingomyelinase (nSMase) activity, but not acidic sphingomyelinase (aSMase) activity, leading to ceramide accumulation
Martin et al., Glycoconj J 2006 (Bone Neoplasms...) : In summary, our studies suggest that TNF-alpha induced N-SMase activation and production of ceramide is required to activate the apoptosis pathway in human osteosarcoma cells
Clarke et al., J Biol Chem 2007 (Lung Neoplasms) : Role for neutral sphingomyelinase-2 in tumor necrosis factor alpha stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 ... Additionally, TNF-alpha increased N-SMase activity rapidly and transiently both endogenously and in cells overexpressing nSMase2
Tellier et al., Mol Cell Biol 2007 : The mechanism of TNF-alpha induced nSMase activation is only partly understood
Clarke et al., Mol Pharmacol 2008 (Lung Neoplasms) : Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells ... However, PMA did not increase in vitro N-SMase activity and PKC-delta did not regulate TNF induced N-SMase activity
Palin et al., Psychopharmacologia 2009 (Weight Loss) : TNFalpha activates neutral sphingomyelinase through the TNF-R1 adapter protein FAN ( factor associated with neutral sphingomyelinase activation ), but a behavioral role of FAN in the brain has never been reported
Wheeler et al., J Neurochem 2009 (Gangliosidosis, GM1) : Tumor necrosis factor-alpha induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors
Philipp et al., Proc Natl Acad Sci U S A 2010 : Although activation of N-SMase by the proinflammatory cytokine TNF was described almost two decades ago, the underlying signaling pathway is unresolved
Clarke et al., Biochem J 2011 (Breast Neoplasms...) : In MCF-7 cells, we found that TNF-a induces late, but not early, increases in N-SMase activity, and that nSMase2 is the primary isoform activated, most likely through post-transcriptional mechanisms
Dinesh et al., Bioinformation 2011 : Recent studies have identified a small region at the very N-terminus of the 55 kDa tumour necrosis factor receptor ( TNF-R55 ), designated the neutral sphingomyelinase activating domain ( NSD ) that is responsible for the TNF induced activation of N-SMase
Liu et al., J Lipid Res 2013 : We also show that FASN overexpression suppresses tumor necrosis factor-a production and nuclear factor-?B activation as well as drug induced activation of neutral sphingomyelinase
Chatterjee et al., J Biol Chem 1994 : We found that TNF-alpha signaling may involve activation of a cell membrane neutral sphingomyelinase (N-SMase) in that within 2.5-5 min of treatment of cells with TNF-alpha there was a 2-fold increase in the activity of N-SMase compared to control
Chatterjee et al., Adv Lipid Res 1993 : According to our hypothetical model shown in Fig. 7, activation of N-SMase via biomodulators, e.g., TNF-alpha , leads to the mobilization of cell surface cholesterol to the interior of the cell
Schütze et al., Immunobiology 1995 : Besides endosomal acidic SMase, TNF also rapidly activates a plasmamembrane associated neural SMase (nSMase) , that, however is not involved in TNF induced NF-kappa B activation
Lawler et al., J Biol Chem 1998 : TNF-alpha is capable of inducing SREBP-1 maturation in a time- and dose dependent manner that is consistent with the kinetics of TNF-alpha mediated activation of neutral sphingomyelinase (N-SMase)