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SMPD2 — TNF
Pathways - manually collected, often from reviews:
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF)
→
sTNF-alpha/TNFR1A complex (TNFRSF1A-TNF)
(modification, collaborate)
Adam-Klages et al., Cell 1996*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF)
→
FAN (NSMAF)
(modification, collaborate)
Adam-Klages et al., Cell 1996*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF)
→
NSMASE (SMPD2)
(modification, collaborate)
Adam-Klages et al., Cell 1996*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A complex (TNFRSF1A-TNF)
→
NSMASE (SMPD2)
(modification, collaborate)
Adam-Klages et al., Cell 1996*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF)
→
RACK1 (GNB2L1)
(modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
sTNF-alpha/TNFR1A/FAN/NSMASE complex (TNFRSF1A-NSMAF-SMPD2-TNF)
→
sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF)
(modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database TNF receptor signaling pathway :
RACK1 (GNB2L1)
→
sTNF-alpha/TNFR1A/FAN/NSMASE/RACK1 complex (TNFRSF1A-NSMAF-SMPD2-GNB2L1-TNF)
(modification, collaborate)
Tcherkasowa et al., J Immunol 2002
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Kreder et al., EMBO J 1999
:
An essential role of FAN in the
TNF induced activation of
N-SMase was demonstrated using thymocytes from FAN knockout mice
Hildt et al., J Exp Med 1999
:
Inhibition of the TNFR-I/FAN ( factor associated with neutral sphingomyelinase ) interaction, which is essential for
TNF-alpha dependent activation of the
neutral sphingomyelinase , either by cell-permeable peptides or by deletion of the FAN binding domain, prevents activation of c-Raf-1 kinase
Chatterjee et al., Chem Phys Lipids 1999
:
A further role of ceramide and N-SMase in atherosclerosis was uncovered by the finding that Ox-LDL and
TNF-alpha stimulated
N-SMase activity ... In contrast to these observations in human hepatocytes,
TNF-alpha mediated
N-SMase activation did not induce apoptosis
Luberto et al., J Biol Chem 2002
:
The compound was then evaluated for its ability to inhibit
tumor necrosis factor (TNF) induced activation of
neutral SMase (N-SMase) in MCF7 cells
Tcherkasowa et al., J Immunol 2002
:
Furthermore,
activation of
N-SMase by
TNF was strongly enhanced when RACK1, FAN, and a noncytotoxic TNF-R55 mutant were expressed concurrently, suggesting RACK1 as a modulator of N-SMase activation
Barsacchi et al., Mol Pharmacol 2003
:
Activation of endothelial nitric-oxide synthase by
tumor necrosis factor-alpha : a novel pathway
involving sequential activation of
neutral sphingomyelinase , phosphatidylinositol-3 ' kinase, and Akt ... The novel pathway of activation of eNOS described here may have broad biological relevance because
neutral sphingomyelinase is
activated not only by
TNF-alpha but also by a variety of other physiological and pathological stimuli
Testai et al., J Neurosci Res 2004
(Oligodendroglioma) :
Both staurosporine and
tumor necrosis factor-alpha (TNF-alpha) induced apoptosis and
activated NSMase in a multiphasic manner in both OPC and HOG cells
Cailleret et al., Circulation 2004
:
In cardiomyocytes obtained from control rats, 25 ng/mL
TNF-alpha increased reactive oxygen species generation and
N-SMase activity ( 500 % and 34 % over basal, respectively ) and decreased the amplitude of [ Ca ( 2+ ) ] ( i ) in response to electrical stimulation ( 22 % below basal )
Zeng et al., J Neurochem 2005
(Infection) :
Abeta,
TNF-alpha , or the combination of both,
increased neutral sphingomyelinase (nSMase) activity, but not acidic sphingomyelinase (aSMase) activity, leading to ceramide accumulation
Martin et al., Glycoconj J 2006
(Bone Neoplasms...) :
In summary, our studies suggest that
TNF-alpha induced
N-SMase activation and production of ceramide is required to activate the apoptosis pathway in human osteosarcoma cells
Clarke et al., J Biol Chem 2007
(Lung Neoplasms) :
Role for
neutral sphingomyelinase-2 in
tumor necrosis factor alpha stimulated expression of vascular cell adhesion molecule-1 (VCAM) and intercellular adhesion molecule-1 (ICAM) in lung epithelial cells : p38 MAPK is an upstream regulator of nSMase2 ... Additionally,
TNF-alpha increased
N-SMase activity rapidly and transiently both endogenously and in cells overexpressing nSMase2
Tellier et al., Mol Cell Biol 2007
:
The mechanism of
TNF-alpha induced
nSMase activation is only partly understood
Clarke et al., Mol Pharmacol 2008
(Lung Neoplasms) :
Regulation of
neutral sphingomyelinase-2 (nSMase2) by
tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells ... However, PMA did not increase in vitro N-SMase activity and PKC-delta did not regulate
TNF induced
N-SMase activity
Palin et al., Psychopharmacologia 2009
(Weight Loss) :
TNFalpha activates
neutral sphingomyelinase through the TNF-R1 adapter protein FAN ( factor associated with neutral sphingomyelinase activation ), but a behavioral role of FAN in the brain has never been reported
Wheeler et al., J Neurochem 2009
(Gangliosidosis, GM1) :
Tumor necrosis factor-alpha induced
neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors
Philipp et al., Proc Natl Acad Sci U S A 2010
:
Although
activation of
N-SMase by the proinflammatory cytokine
TNF was described almost two decades ago, the underlying signaling pathway is unresolved
Clarke et al., Biochem J 2011
(Breast Neoplasms...) :
In MCF-7 cells, we found that
TNF-a induces late, but not early, increases in
N-SMase activity, and that nSMase2 is the primary isoform activated, most likely through post-transcriptional mechanisms
Dinesh et al., Bioinformation 2011
:
Recent studies have identified a small region at the very N-terminus of the 55 kDa tumour necrosis factor receptor ( TNF-R55 ), designated the neutral sphingomyelinase activating domain ( NSD ) that is responsible for the
TNF induced activation of
N-SMase
Liu et al., J Lipid Res 2013
:
We also show that FASN overexpression suppresses
tumor necrosis factor-a production and nuclear factor-?B activation as well as drug induced
activation of
neutral sphingomyelinase
Chatterjee et al., J Biol Chem 1994
:
We found that
TNF-alpha signaling may
involve activation of a cell membrane
neutral sphingomyelinase (N-SMase) in that within 2.5-5 min of treatment of cells with TNF-alpha there was a 2-fold increase in the activity of N-SMase compared to control
Chatterjee et al., Adv Lipid Res 1993
:
According to our hypothetical model shown in Fig. 7,
activation of
N-SMase via biomodulators, e.g.,
TNF-alpha , leads to the mobilization of cell surface cholesterol to the interior of the cell
Schütze et al., Immunobiology 1995
:
Besides endosomal acidic SMase,
TNF also rapidly
activates a plasmamembrane associated neural SMase
(nSMase) , that, however is not involved in TNF induced NF-kappa B activation
Lawler et al., J Biol Chem 1998
:
TNF-alpha is capable of inducing SREBP-1 maturation in a time- and dose dependent manner that is consistent with the kinetics of
TNF-alpha mediated activation of
neutral sphingomyelinase (N-SMase)