Gene interactions and pathways from curated databases and text-mining

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NLRP3 — TNF

Text-mined interactions from Literome

O'Connor et al., J Immunol 2003 : We report that TNF-alpha and ligands recognized by multiple Toll-like receptors rapidly induce CIAS1 gene expression in primary human monocytes
Rosengren et al., Ann Rheum Dis 2005 (Arthritis, Rheumatoid...) : FLS from RA and OA tissue expressed low baseline levels of cryopyrin transcripts that were induced by tumour necrosis factor alpha (TNFalpha)
Franchi et al., Eur J Immunol 2008 (Inflammation) : The requirement of the Nlrp3 inflammasome was specific for IL-1beta in that secretion of TNF-alpha was independent of Nlrp3 or Asc
Qiu et al., Innate Immun 2011 (Carcinoma, Squamous Cell) : Stimulation of NLRP3 with E. coli RNA led to the highest induction of TNF-a , IL-6, IL-12p40, RANTES and IFN-ß, whereas TLR7, TLR3, TLR9, NOD1 and NOD2 agonists had lower effects