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MAP2K3 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Manna et al., Biochem Pharmacol 1999
:
Beta-lapachone also abolished
TNF induced activation of AP-1, c-Jun N-terminal kinase, and
mitogen activated protein kinase kinase ( MAPKK or MEK )
Manna et al., Oncogene 1999
:
gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited
TNF induced activation of JNK and
mitogen activated protein kinase kinase
Manna et al., J Biol Chem 2000
:
hCG abrogated the
TNF induced activation of
mitogen activated protein kinase kinase and c-Jun N-terminal kinase required for NF-kappaB and AP-1, respectively
Manna et al., J Immunol 2000
:
Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents,
inhibited the
TNF induced activation of transcription factor AP-1, and suppressed the TNF induced activation of c-Jun N-terminal kinase and
mitogen activated protein kinase kinase
Manna et al., J Immunol 2000
:
Resveratrol also inhibited the
TNF induced
activation of
mitogen activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF induced cytotoxicity and caspase activation
Hashimoto et al., Br J Pharmacol 2001
:
To clarify these issues, we examined the effect of NAC on
TNF-alpha induced activation of p38 MAP kinase,
MAP kinase kinase (MKK) 3 and MKK6 which are upstream regulators of p38 MAP kinase, and p38 MAP kinase mediated IL-8 production
Cha et al., J Pharmacol Exp Ther 2006
:
The Syk inhibitor also decreased
TNFalpha induced
mitogen activated protein kinase kinase ( MKK ) 4 phosphorylation but not MKK3 and MKK6 phosphorylation, which is consistent with its selective sparing of p38
Manna et al., J Biol Chem 1998
:
In addition, Mn-SOD blocked the
TNF mediated activation of activated protein-1, stress activated c-Jun protein kinase, and
mitogen activated protein kinase kinase