◀ Back to TNF

IRS2 — TNF

Text-mined interactions from Literome

Wang et al., Biochem Biophys Res Commun 2006 (Insulin Resistance) : On the other hand, addition of TNF-alpha or IL-6 neutralizing antibodies to the supernatant of co-culture recovered both IRS-2 phosphorylation and Akt activation
Lorenzo et al., J Anim Sci 2008 (Insulin Resistance) : Conversely, Ser phosphorylation of IRS-2 mediated by TNF-alpha activation of mitogen activated protein kinase was the mechanism found in brown adipocytes
Bouzakri et al., J Biol Chem 2009 (Diabetes Mellitus, Type 2) : Silencing mitogen activated protein 4 kinase 4 ( MAP4K4 ) protects beta cells from tumor necrosis factor-alpha induced decrease of IRS-2 and inhibition of glucose stimulated insulin secretion
Natalicchio et al., Endocrinology 2010 : When cells were pretreated with exendin-4, TNFalpha induced JNK and IRS-1/2 serine phosphorylation was markedly reduced, Akt phosphorylation was increased, caspase-3 and Bcl-2 protein levels were restored to normal, and TNFalpha induced apoptosis was inhibited by 50 %
Valverde et al., Endocrinology 1998 (Insulin Resistance) : Our results indicate that TNF-alpha induced an IRS-2- but not IRS-1 mediated insulin resistance on glucose transport and lipid synthesis in fetal brown adipocytes