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IL17A — TNF

Text-mined interactions from Literome

Lenarczyk et al., Clin Exp Immunol 2000 : We therefore investigated the in vitro IL-17 response to a variety of mitogens and antigens, and compared the IL-17 response to interferon-gamma (IFN-gamma), IL-4, IL-10 and TNF-alpha
Ye et al., Am J Respir Cell Mol Biol 2001 (Klebsiella Infections...) : Moreover, overexpression of IL-17 in the pulmonary compartment using a recombinant adenovirus encoding murine IL-17 ( AdIL-17 ) resulted in the local induction of tumor necrosis factor-alpha , IL-1beta, macrophage inflammatory protein-2, and granulocyte colony stimulating factor ( G-CSF ) ; augmented polymorphonuclear leukocyte recruitment ; and enhanced bacterial clearance and survival after challenge with K. pneumoniae
Shimada et al., J Immunol 2002 : Furthermore, IL-17, IL-1beta, and TNF-alpha induced a rapid activation of extracellular signal related kinase p42/44 and p38 MAPKs, and specific MAPK inhibitors ( SB203580, PD98059, and U0216 ) significantly reduced IL-17- , IL-1beta-, or TNF-alpha induced IL-6 secretion, indicating the role of MAPKs in the induction of IL-6
Vuolteenaho et al., Osteoarthritis Cartilage 2002 (Osteoarthritis, Knee) : TNFalpha-antagonists infliximab and etanercept inhibited TNFalpha induced NO production in a dose dependent manner but they had no effect on IL-1beta-, IL-17- and LPS stimulated NO synthesis
Maertzdorf et al., J Immunol 2002 (Keratitis, Herpetic) : IL-17 also enhanced TNF-alpha- and IFN-gamma induced secretion of macrophage-inflammatory proteins 1alpha and 3alpha, while inhibiting the induced secretion of RANTES
Granet et al., Arthritis Res Ther 2004 (Arthritis, Rheumatoid...) : IL-1 and TNF-alpha induced mRNA expression of c-jun while IL-17 had no effect
Granet et al., Cytokine 2004 : IL-1 and TNF-alpha induced most of these transcription factors while IL-17 had a weak effect
Stamp et al., J Rheumatol 2004 : Recombinant IL-17 upregulated synoviocyte COX-2 expression and enhanced TNF-a stimulated synoviocyte COX-2 expression
Faour et al., J Biol Chem 2005 (Arthritis, Rheumatoid) : We have investigated the potential immunomodulatory properties of prostaglandin E2 ( PGE2 ) by examining the molecular mechanism by which the eicosanoid suppresses T-cell derived interleukin-17 (IL-17) induced TNF-alpha mRNA expression and protein synthesis in human macrophages and rheumatoid arthritis affected synovial fibroblasts ... Using human leukemic monocytic THP-1 cells stably transfected with WT and dominant negative mutant expression constructs of Egr-1, cotransfected or not with a WT pTNF-615SVOCAT construct, we observed that PGE2 inhibition of IL-17 stimulated TNF-alpha mRNA expression and promoter activity was dependent on Egr-1 expression, as mutants of Egr-1, alone or in combination, markedly abrogated any inhibitory effect of PGE2
Akaogi et al., Endocr Metab Immune Disord Drug Targets 2006 (Arthritis, Experimental...) : PGE2 is also produced in response to proinflammatory cytokines, which in turn negatively regulates both IL-17 and TNF-alpha expression and TNF/IL-1 induced activation of fibroblast-like synoviocytes through EP2/EP4 receptors, resulting in the modulation of proinflammatory cascades ... At the same time, PGE2 suppresses osteoclastogenesis by inhibiting M-CSF expression of fibroblast-like synoviocytes as well as both IL-17 and IL-17 induced TNF-alpha expression of macrophages
Beklen et al., J Dent Res 2007 (Periodontitis) : MMPs, IL-1, and TNF are regulated by IL-17 in periodontitis ... IL-17 was less potent as a direct MMP inducer than IL-1beta and TNF-alpha, but it induced IL-1beta and TNF-alpha production from macrophages, and IL-6 and IL-8 from gingival fibroblasts
Kim et al., Immunol Lett 2007 (Arthritis, Rheumatoid...) : TLR stimulation of RA-FLS also induced the production of IL-1beta and TNF-alpha to a lesser extent ; however, it had no effect on IL-17 production
Yamaguchi et al., J Immunol 2007 (Arthritis, Experimental...) : In vitro, IL-17A, IL-17B, IL-17C , and IL-17F induced TNF-alpha production in mouse peritoneal exudate cells
Gu et al., Br J Haematol 2008 (Anemia, Aplastic) : IL-17 stimulation also resulted in the production of TNF-alpha
Hölttä et al., Inflamm Bowel Dis 2008 (Crohn Disease) : The effect of IL-17 on IL-8 and TNF-alpha mRNA expression in epithelial cell line Caco-2 was studied ... IL-17 enhanced the IL-8 and TNF-alpha response of the epithelial cell line to lipopolysaccharide (LPS) in vitro
Hashizume et al., Rheumatology (Oxford) 2008 (Arthritis, Rheumatoid) : On the other hand, TNF-alpha and IL-17 did not induce RANKL expression, although TNF-alpha, IL-17 or IL-1beta stimulated cell growth and IL-6 production
Zhu et al., Breast Cancer Res 2008 (Breast Neoplasms...) : In contrast, TNF promoted secretion of MMPs but IL-17 did not augment TNF , indicating that IL-17 acts via an independent mechanism
Zdravkovic et al., Mol Immunol 2009 (Diabetes Mellitus, Experimental) : RT-PCR analysis of mRNA transcripts of diabetogenic cytokines revealed that the expression of TNF-alpha , and IFN-gamma was significantly enhanced in pancreatic lymph nodes by day 10 after diabetes induction in ST2-deficient mice in comparison with wild type BALB/c mice while IL-17 was detected only in ST2 ( -/- ) mice by day 21
Ortega et al., J Leukoc Biol 2009 (Psoriasis) : Blocking of TNF-alpha activity inhibits TCR mediated activation and IL-17 production
Hillyer et al., Rheumatology (Oxford) 2009 (Arthritis, Rheumatoid) : IL-17A protein was detected in approximately 40 % of the supernatants and IL-17A blockade, in IL-17A producing cultures, resulted in a small but significant inhibition of TNF-alpha ( 38 % ), IL-1beta ( 23 % ) and IL-6 ( 22 % )
Hueber et al., J Immunol 2010 (Arthritis, Rheumatoid) : Furthermore, we demonstrated in vitro that mast cells produced RORC dependent IL-17A upon stimulation with TNF-alpha , IgG complexes, C5a, and LPS
Baldeviano et al., Circ Res 2010 (Cardiomyopathies...) : Flow cytometric and cytokine analysis revealed an important role for IL-17A in heart-specific upregulation of IL-6, TNFalpha , and IL-1beta and the recruitment of CD11b ( + ) monocyte and Gr1 ( + ) granulocyte populations into the heart
Zhang et al., Arch Oral Biol 2010 : The expression of COX-2, IL-1alpha, IL-6, IL-8, IL-11, and TNF-alpha , as well as PGE ( 2 ) production increased in the presence of IL-17A , whereas COX-1 expression did not change
Bian et al., Stem Cells 2010 (Inflammation) : Exogenous IL-17A stimulated the expression and production of inflammatory cytokines ( TNF-a , IL-6, and IL-1ß ) and chemokine IL-8 by HLECs
Freches et al., Clinical and vaccine immunology : CVI 2011 (Tuberculosis) : Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine treated, Mycobacterium bovis BCG vaccinated mice
Kotobuki et al., Pigment Cell Melanoma Res 2012 (Autoimmune Diseases...) : In terms of local cytokine network in the skin, IL-17A dramatically induced IL-1ß, IL-6, and TNF-a production in skin-resident cells such as keratinocytes and fibroblasts
Queiroz-Junior et al., J Clin Periodontol 2012 (Actinobacillus Infections...) : Anti-TNF-a and antiseptic therapies prevented the development and exacerbation of infectious-PD. Anti-TNF-a therapy also resulted in reduced expression of IFN-?, TNF-a and IL-17 in maxillae
Gelderblom et al., Blood 2012 (Brain Ischemia...) : IFN-? produced by CD4 ( + ) T cells induced TNF-a production in macrophages, whereas IL-17A secreted by ?d T cells led to neutrophil recruitment
Guan et al., Immunotherapy 2012 (Colitis) : In vitro inhibition tests of sera from vaccine immunized mice were performed using IL-17 induced IL-6 production by NIH 3T3 cells and IL-17 induced TNF production by macrophages ... Furthermore, in vitro study revealed that serum IL-17-specific IgG from vaccine immunized mice significantly enhanced IL-17 induced IL-6 production and IL-17 induced TNF production dose-dependently
Nonaka et al., The World Allergy Organization journal 2009 : This synergy was observed by stimulation with TNF-a ; plus IL-17A or IL-17F, but not IL-17E
Gruber et al., Biotech Histochem 2013 : We evaluated IL-17 using immunolocalization in herniated and non herniated human discs, IL-17 gene expression, and the production of IL-17 by annulus cells cultured in three dimensions in the presence of IL-1ß or TNF-a
Yang et al., Clin Dev Immunol 2013 (Arthritis, Experimental...) : Baicalin also blocked IL-17 induced intercellular adhesion molecule 1, vascular cell adhesion molecule 1, IL-6, and tumor necrosis factor-alpha mRNA expression in cultured synoviocytes
Jovanovic et al., J Immunol 1998 (Inflammation) : IL-10 exerted a significant suppressive effect on IL-17 induced TNF-alpha release ( 99 %, p < 0.02 ), while the inhibitory effects of IL-4, IL-13, and TGF-beta2 on TNF-alpha secretion were partial ( 48, 10, and 23 %, respectively )