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ABCA1 — TNF

Text-mined interactions from Literome

Gerbod-Giannone et al., Proc Natl Acad Sci U S A 2006 : TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells ... The induction of ABCA1 by TNFalpha is reduced by 65 % in IkappaB kinase beta-deficient macrophages and by 30 % in p38alpha-deficient macrophages, but not in jun kinase 1 ( JNK1 ) - or JNK2-deficient macrophages
Mei et al., Cell Biol Int 2007 : This study investigates the effects of tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) on ABCA1 expression and cholesterol content in THP-1 macrophage derived foam cells
Zhao et al., Clin Chim Acta 2008 : The expression of ABCA1 was increased by 5 ng/ml or 10 ng/ml TNF-alpha compared with control group, and was inhibited by 20 ng/ml TNF-alpha ... TNF-alpha affects cholesterol efflux and ABCA1 expression of adipocytes, and the pathway of PPARgamma-LXRalpha-ABCA1 is probably involved
Edgel et al., Atherosclerosis 2010 : Tumor necrosis factor-alpha and lymphotoxin-alpha increase macrophage ABCA1 by gene expression and protein stabilization via different receptors ... Here we examined the role of TNF receptors (TNFRs) in ABCA1 induction and tested the effects of lymphotoxin-alpha (LT), another TNF family member, on macrophage ABCA1 levels ... We studied TNFR2 ( -/- ) and TNFR1 ( -/- ) /R2 ( -/- ) mice and found that both receptors are necessary for maximal induction of ABCA1 by TNF ... TNF requires both of its receptors to maximally induce ABCA1
Field et al., J Lipid Res 2010 : The regulation of ABCA1 and HDL cholesterol efflux by TNF-alpha was investigated in the human intestinal cell line Caco-2
Zhang et al., Circulation 2010 (Inflammation) : Tumor necrosis factor-alpha reduced both ABCA1 and SR-BI expression and impaired cholesterol efflux from partially differentiated adipocytes