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IL1A — SMC6

Text-mined interactions from Literome

Alexander et al., J Clin Invest 2012 (Plaque, Atherosclerotic) : In addition, MMP3 was required for IL-1 induced SMC invasion of Matrigel in vitro
Alexander et al., Physiol Genomics 2012 (Inflammation...) : However, SMCs within atherosclerotic plaques can also express a number of proinflammatory genes, and in cultured SMCs the inflammatory cytokine IL-1ß represses SMC marker gene expression and induces inflammatory gene expression ... Genome-wide gene expression analysis of IL-1ß- or PDGF-DD treated SMCs revealed that although both stimuli repressed SMC differentiation marker gene expression, IL-1ß distinctly induced expression of proinflammatory genes, while PDGF-DD primarily induced genes involved in cell proliferation ... Promoters of inflammatory genes distinctly induced by IL-1ß exhibited over-representation of NF-?B binding sites, and NF-?B inhibition in SMCs reduced IL-1ß induced upregulation of proinflammatory genes as well as repression of SMC differentiation marker genes ... Finally, immunofluorescent staining of mouse atherosclerotic lesions revealed the presence of cells positive for the marker of an IL-1ß stimulated inflammatory SMC , chemokine (C-C motif) ligand 20 ( CCL20 ), but not the PDGF-DD induced gene, regulator of G protein signaling 17 ( RGS17 )
Loppnow et al., Prog Clin Biol Res 1994 : IL1Ra reduced the activation of EC and SMC by recombinant IL1 , as well as the activation of SMC with vascular cell derived membrane IL1 in coculture experiments