◀ Back to SKP2
FOXO1 — SKP2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
FOXO1
→
SKP2
(decreases, FOXO1 Activity)
Evidence: The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full...
-
OpenBEL Selventa BEL large corpus:
FOXO1
→
SKP2
(decreases, FOXO1 Activity)
Huang et al., Proc Natl Acad Sci U S A 2005*
Evidence: Modified assertion
-
NCI Pathway Database FoxO family signaling:
FOXO1 (FOXO1)
→
FOXO1/SKP2 complex (FOXO1-SKP2)
(modification, collaborate)
Huang et al., Proc Natl Acad Sci U S A 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database FoxO family signaling:
FOXO1 (FOXO1)
→
SKP2 (SKP2)
(modification, collaborate)
Huang et al., Proc Natl Acad Sci U S A 2005*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database FoxO family signaling:
FOXO1/SKP2 complex (FOXO1-SKP2)
→
SKP2 (SKP2)
(modification, collaborate)
Huang et al., Proc Natl Acad Sci U S A 2005*
Evidence: mutant phenotype, physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Huang et al., Proc Natl Acad Sci U S A 2005
(Lymphoma) :
Skp2 inhibits
FOXO1 in tumor suppression through ubiquitin mediated degradation ... Here we demonstrate that
Skp2 , an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex, interacts with, ubiquitinates, and
promotes the degradation of
FOXO1 ... This effect of
Skp2 requires Akt-specific phosphorylation of
FOXO1 at Ser-256
Ward et al., Endocrinology 2008
(Endometrial Neoplasms) :
Using small interfering RNA technology, we demonstrated that the low levels of FOXO1 protein were due to the involvement of Skp2, an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex, given that silencing
Skp2 increased
FOXO1 protein expression in Ishikawa cells