◀ Back to RELA
RELA — SHH
Text-mined interactions from Literome
Schmidt-Ullrich et al., Development 2006
:
We show that
NF-kappaB activation is
essential for induction of
Shh and cyclin D1 expression and subsequent placode down growth
Nakashima et al., Cancer Res 2006
(Carcinoma, Pancreatic Ductal...) :
We hypothesized that
nuclear factor-kappaB (NF-kappaB) , a hallmark transcription factor in inflammatory responses,
contributes to the overexpression of
Shh in pancreatic cancer ...
NF-kappaB induced
Shh expression actually activated the Hh pathway in a ligand dependent manner and enhanced cell proliferation in pancreatic cancer cells
Heo et al., Stem Cells 2007
(Calcium Signaling...) :
Subsequently,
Shh increased the
nuclear factor (NF)-kappaB p65 phosphorylation, which was inhibited by blocking PKC and EGFR tyrosine kinase
Kasperczyk et al., FASEB J 2009
(Neoplasms) :
To explore mechanisms controlling sonic hedgehog (Shh) expression in human cancers, we investigated
regulation of
Shh by the transcription factor
NF-kappaB ... Specific
NF-kappaB inhibition by inhibitory NF-kappaBalpha ( Ikappa-Balpha ) superrepressor or p65 knockdown
inhibits NF-kappaB induced
Shh promoter activation and Shh expression ...
NF-kappaB mediated
Shh expression promotes proliferation and confers resistance to TRAIL induced apoptosis
Cui et al., Cancer Sci 2010
(Breast Neoplasms...) :
Taken together, these observations suggest that Shh overexpression is a critical event in breast carcinogenesis, and Shh promoter hypomethylation and
NF-kappaB up-regulation are
responsible for the up-regulation of
Shh