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IL12B — RELA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Delgado et al., J Biol Chem 1999
:
VIP and PACAP
inhibit IL-12 ( p40 ) gene expression by affecting both
NF-kappaB binding and the composition of the Ets-2 binding complex
Kang et al., Immunol Lett 1999
:
Our results show that TPCK and TLCK inhibit
NFkappaB mediated
IL-12 production in macrophages
Du et al., Cell Immunol 2000
:
SEB induced expression of the
IL-12/p40 gene
involves activation and nuclear translocation of
nuclear factor kappaB (NF-kappaB)
Schindler et al., J Immunol 2001
:
NF-kappa B , which mediates IL-18 effects in T cells, was only weakly
activated by
IL-12 and/or IL-18 in macrophages
Grumont et al., J Exp Med 2001
:
This data establishes the IL-12 p35 gene as a new target of c-Rel and shows that the
regulation of
IL-12 p70 expression at the transcriptional level by
Rel/NF-kappaB is controlled through both the p35 and p40 genes in a cell type-specific fashion
Säemann et al., J Leukoc Biol 2002
:
In particular, n-butyrate prevents homotypic DC clustering,
inhibits IL-12 while sparing IL-10 production, and at the molecular level, blocks
NF-kappa B translocation
Maruyama et al., J Immunol 2003
:
The induction of the
IL-12 p40 gene is
regulated by
NF-kappaB in the presence of IFN-gamma
Kuroki et al., Cancer Immunol Immunother 2003
:
These results indicate that uptake of OK-432 by imMo-DCs is an early critical event for IL-12 p70 production and that
NF-kappaB activation induced by OK-432 also
contributes partially to
IL-12 p70 production
Ma et al., J Immunol 2004
:
Taken together, our results suggest that DXM may
inhibit IL-12p40 production in LPS stimulated human monocytic cells by down regulating the activation of JNK MAPK, the AP-1, and
NF-kappaB transcription factors
Hoentjen et al., Blood 2005
:
In this study, we investigated the
role of
nuclear factor-kappa B (NF-kappaB) and signal transducers and activators of transcription 3 ( STAT3 ) in lipopolysaccharide (LPS) induced
IL-12p40 gene expression in bone marrow derived-dendritic cells ( BMDCs ) isolated from wild-type ( WT ) and IL-10 ( -/- ) mice ... In conclusion, dysregulated LPS induced
IL-12p40 gene expression in IL-10 ( -/- ) mice is
due to enhanced
NF-kappaB recruitment to the IL-12p40 promoter in the absence of activated STAT3
Mason et al., Infect Immun 2004
:
Recent studies suggest that components of the TLR pathway are required for the production of IL-12 in response to the parasite Toxoplasma gondii ; however, the production of
IL-12 in response to this parasite is
independent of
NF-kappaB activation
Chang et al., Mol Cells 2004
(Inflammation...) :
Activation of
NF-kappaB leads to the production of proinflammatory cytokines such as
IL-12 and TNF-alpha that are involved in innate and adaptive immunity
Kabashima et al., FEBS Lett 2004
(Hypersensitivity, Delayed...) :
Here, we found that our recently synthesized
NF-kappaB inhibitor attenuated an ovalbumin-specific delayed-type hypersensitivity response in vivo and
suppressed production of
IL-12 by dendritic cells and TH1 cytokines by T cells in vitro
Rahim et al., Immunology 2005
:
In a complementary experiment, in vitro transient expression of p65 NF-kappaB could not rescue the inhibitory effect of IL-10 on IL-12 production, suggesting that
NF-kappaB alone was not
sufficient to restore
IL-12 production during IL-10 treatment
Kang et al., Cell Signal 2005
(Autoimmune Diseases) :
IL-12 production is differentially
regulated through multiple pathways, which can be classified as follows :
nuclear factor-kappaB (NF-kappaB) and other transcription factors, p38 mitogen activated protein ( MAP ) kinase, cyclic adenosine monophosphate ( cyclic AMP ) -modulating molecules, cell membrane ion channels and pumps, nitric oxide ( NO ), and receptors
Yue et al., Proc Natl Acad Sci U S A 2005
:
Selective
NF-kappaB inhibition
blocked this CD1d stimulated
IL-12 production
Filipe-Santos et al., J Exp Med 2006
(Genetic Predisposition to Disease...) :
IL-12 production was also impaired as the
result of a specific defect in NEMO- and
NF-kappaB/c-Rel mediated CD40 signaling after the stimulation of monocytes and dendritic cells by CD40L expressing T cells and fibroblasts, respectively ... They also demonstrate the importance of the T cell- and CD40L triggered, CD40-, and
NEMO/NF-kappaB/c-Rel mediated
induction of
IL-12 by monocyte derived cells for protective immunity to mycobacteria in humans
Usluoglu et al., Eur J Immunol 2007
:
Different signal pathways mediate LPS induced expression of
IL-12 and
involve PI3K, MAPK and the transcription factor
NF-kappaB
Homma et al., J Interferon Cytokine Res 2007
:
The Th2 transcription factor c-Maf
inhibits IL-12p35 gene expression in activated macrophages by targeting
NF-kappaB nuclear translocation
Jayakumar et al., Infect Immun 2008
:
The inhibition of
NF-kappaB activation by the pretreatment of DC with caffeic acid phenethyl ester
blocks L. major induced IRF-1 and IRF-8 activation and
IL-12 expression
Argueta-Donohué et al., Exp Parasitol 2008
:
Leishmania mexicana :
participation of
NF-kappaB in the differential production of
IL-12 in dendritic cells and monocytes induced by lipophosphoglycan ( LPG )
Ju et al., J Immunol 2008
(Arthritis, Experimental...) :
IL-23 induces receptor activator of
NF-kappaB ligand expression on CD4+ T cells and promotes osteoclastogenesis in an autoimmune arthritis model
Ma et al., J Biol Chem 2009
(Acquired Immunodeficiency Syndrome) :
HIV-1 Nef
inhibits lipopolysaccharide induced
IL-12p40 expression by inhibiting JNK activated
NFkappaB in human monocytic cells ... We have previously shown that lipopolysaccharide (LPS) induced
IL-12p40 production in monocytic cells is
regulated by
NFkappaB and AP-1 transcription factors through the activation of two distinct upstream signaling pathways, namely the c-Jun-N-terminal kinase (JNK) and the calmodulin dependent protein kinase-II activated pathways
Rigaux et al., Allergy 2009
(Hypersensitivity) :
IL-12 p40 secretion was
dependent on
nuclear factor-kappaB (NF-kappaB) , mitogen activated protein ( MAP ) kinases, Toll-like receptor 2 (TLR2), TLR9 and on the bacterial teichoic acid composition
Kortylewski et al., Cancer Cell 2009
(Neoplasms) :
Furthermore, Stat3 inhibits
NF-kappaB/c-Rel dependent
IL-12/p35 gene expression in tumor associated dendritic cells
Kang et al., Cytokine 2009
:
Induction of
IL-12 by LMM in peritoneal macrophages
involved NF-kappaB , p38 and JNK, but not ERK1/2
Li et al., Immunol Lett 2010
(Arthritis, Rheumatoid...) :
IL-23 induces receptor activator of
NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways
Fukuda et al., Int J Oncol 2010
(Carcinoma, Squamous Cell...) :
Furthermore, luciferase reporter assay showed that
IL-23 strongly
induces RelA activity, and confirmed this finding by knockdown of IL-23 using RNA interference
Antonios et al., J Immunol 2010
(MAP Kinase Signaling System) :
Our results showed that p38 MAPK,
NF-kappaB , and IRF-1 were
involved in
IL-12p40 production induced by NiSO ( 4 )
Kato et al., Glycoconj J 2010
:
SIGNR1 ligation on murine peritoneal macrophages
induces IL-12 production through
NFkappaB activation ... These results indicate that SIGNR1 mediated intercellular signaling may
induce production of cytokines such as
IL-12 through
NFkappaB activation
Mazzeo et al., Eur J Immunol 1998
:
Decreased
IL-12 production and Th1 cell development by acetyl salicylic acid
mediated inhibition of
NF-kappaB ... These results suggest that the inhibition of
NF-kappaB activation by ASA
leads to down-regulation of
IL-12 production and inhibition of Th1 cell development