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FLT3 — RELA
Text-mined interactions from Literome
Takahashi et al., Leuk Res 2005
(Leukemia, Myeloid, Acute) :
In this study, we addressed the
role of
Flt3 in the activation of
nuclear factor-kappa B (NF-kappaB) , which is a target molecule of these kinase pathways
Griessinger et al., Leukemia 2007
(Leukemia, Myeloid, Acute) :
Using Ba/F3 murine pre-B cells transfected with various mutants of FLT3 ( ITD, D835V, D835Y ) and the MV4-11 human AML line, we show that normal or oncogenic stimulation of
FLT3 led to activation of
NF-kappaB
Grosjean-Raillard et al., Apoptosis 2008
(Leukemia, Myeloid, Acute...) :
Flt3 receptor inhibition
reduces constitutive
NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia ... Chemical inhibition or knockdown of
Flt3 with small interfering RNAs
reduced NFkappaB activation in MDS and AML cell lines, as well as in primary CD34 ( + ) bone marrow cells from patients, causing apoptosis