Rocha et al., EMBO J 2005
:
Here we demonstrate that ARF induces the ATR- and Chk1 dependent phosphorylation of the RelA transactivation domain at threonine 505, a site required for ARF dependent repression of RelA transcriptional activity
Rocha et al., Cell cycle (Georgetown, Tex.) 2005
:
ARF induced Chk1 phosphorylates RelA on threonine 505, a residue in its transactivation domain, thus inhibiting NF-kappaB 's ability to stimulate anti-apoptotic gene expression
Campbell et al., Cancer Res 2006
(Bone Neoplasms...) :
Cisplatin mimics ARF tumor suppressor regulation of RelA ( p65 ) nuclear factor-kappaB transactivation