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CDKN1A — RAD51

Text-mined interactions from Literome

Raderschall et al., J Cell Sci 2002 (Chromosome Aberrations) : In contrast, Rad51 antisense inhibition reduces p21 protein levels and sensitizes cells to etoposide treatment ... Downregulation of p21 inhibits Rad51 foci formation in both normal and Rad51 overexpressing cells ... Collectively, our results show that Rad51 expression, Rad51 foci formation and p21 expression are interrelated, suggesting a functional link between mammalian Rad51 protein and p21 mediated cell cycle regulation
Liu et al., Anticancer Res 2011 (Breast Neoplasms) : The p53 pathway was involved in the synergism of RAD001 and carboplatin on breast cancer cell proliferation and apoptosis, since the synergistic effect was demonstrated in all tested breast cancer cell lines with wild-type p53 and the use of p53 inhibitor partially antagonized the effect of RAD001 and carboplatin on p53 and p21 expression, as well as their inhibitory effect on cell proliferation