Gene interactions and pathways from curated databases and text-mining

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NBN — PML

Text-mined interactions from Literome

Lallemand-Breitenbach et al., J Exp Med 2001 : In acute promyelocytic leukemia, PML/retinoic acid receptor (RAR) alpha expression disrupts NBs , but therapies such as retinoic acid or arsenic trioxide ( As2O3 ) restore them
Peche et al., Cell Death Differ 2012 : This reduction in PML post-translational modification promotes defects in PML-NBs formation
Sivachandran et al., J Virol 2012 : Our results provide the first function for EBNA1 in lytic infection and show that EBNA1 interactions with PML IV lead to a loss of PML nuclear bodies (NBs) that promotes lytic infection