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PDB1 — PKD2

Text-mined interactions from Literome

Waldron et al., J Biol Chem 2000 : The specific phospholipase C inhibitor, partly blocked H ( 2 ) O ( 2 ) -mediated but not PDB mediated PKD activation
Iglesias et al., J Biol Chem 1998 : Here, we show that substitution of Ser744 and Ser748 with alanine ( PKD-S744A/S748A ) completely blocked PKD activation induced by phorbol-12,13-dibutyrate (PDB) treatment of intact cells as assessed by autophosphorylation and exogenous syntide-2 peptide substrate phosphorylation assays ... Two-dimensional tryptic phosphopeptide analysis obtained from PKD mutants immunoprecipitated from 32P labeled transfected COS-7 cells showed that two major spots present in the PDB stimulated wild type PKD or the kinase-dead PKD-D733A phosphopeptide maps completely disappeared in the kinase-deficient triple mutant PKD-D733A/S744E/S748E
Paolucci et al., Cancer Res 1999 (Carcinoma, Small Cell...) : PKD activation induced by PDB in these SCLC cell lines was completely abrogated by treatment of the cells with the PKC inhibitor GF 109203X ( GF I ) at concentrations ( 0.5-2.5 microM ) that did not inhibit PKD activity when added directly to the in vitro kinase assays ... The PKC inhibitors Ro 31-8220 and Go 7874 also blocked PKD activation in response to PDB