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IRF6 — PKD2
Text-mined interactions from Literome
Song et al., Brain Res 2007
(Myelitis) :
Particularly, PKCalpha might be critical for
LPS induced
PKD activation since the PKCbeta inhibitor ( 100 nM ) observed no effect on the phosphorylation of PKD ... These results demonstrated for the first time that
PKD could be
activated by
LPS in spinal neurons, might via the IL-1beta/PKCalpha pathway
Duan et al., Inflamm Res 2011
(Drug-Induced Liver Injury...) :
The results indicated that LPS/D : -GalN administration markedly
induced hepatic
PKD activation, lethality and liver injury, while pretreatment of the PKD inhibitor Gö6976 significantly inhibited
LPS induced PKD activation, improved the survival of LPS/D : -GalN administered mice and attenuated LPS/D : -GalN induced liver injury, as evidenced by reduced levels of serum aminotransferases as well as reduced histopathological changes