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FSHB — PITX2

Text-mined interactions from Literome

Suszko et al., Mol Cell Endocrinol 2008 : Present data demonstrate that Pitx2 is not only sufficient, but also necessary for FSHbeta gene transcription, as a siRNA mediated downregulation of Pitx2 protein expression abrogates both Smad3- and activin mediated stimulation of the FSHbeta promoter
Lamba et al., Endocrinology 2008 : Transfection of PITX1 or PITX2C in heterologous cells stimulated both murine and human Fshb/FSHB promoter-reporter activities, and in both cases, mutation of the critical cis-element abrogated these effects ... Transfecting dominant negative forms of PITX1 or PITX2C or knocking down PITX1 or -2 expression by RNA interference in LbetaT2 cells inhibited murine Fshb transcription, confirming roles for endogenous PITX proteins ... Both PITX1 and PITX2C interacted with Smad3 ( an effector of the activin signaling cascade in these cells ) in coprecipitation experiments, and the PITX binding site mutation greatly inhibited Smad2/3/4 stimulated Fshb transcription ... In summary, both PITX1 and PITX2C regulate murine and human Fshb/FSHB transcription through a conserved cis-element in the proximal promoter