Goel et al., Trends Endocrinol Metab 2004
:
New work shows that phosphorylation of RKIP by protein kinase C disassociates RKIP from Raf-1 and stimulates its binding to, and inhibition of G-protein coupled receptor kinase 2 ( GRK2 )
Keller et al., Biochem Pharmacol 2004
(Neoplasms) :
The phosphorylated RKIP binds to and inhibits G-protein coupled receptor kinase , resulting in sustained G-protein signaling
Klysik et al., Cell Signal 2008
(Alzheimer Disease...) :
In its phosphorylated state, RKIP-1 dissociates from Raf-1 and inhibits GRK-2 , a negative regulator of G-protein coupled receptors ( GPCRs )