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NR4A2 — PIAS4

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: PIAS4 — NR4A2 (in vitro) Galleguillos et al., J Biol Chem 2004*
• IRef Hprd Interaction: PIAS4 — NR4A2 (in vivo) Galleguillos et al., J Biol Chem 2004*
• IRef Hprd Interaction: PIAS4 — NR4A2 (two hybrid) Galleguillos et al., J Biol Chem 2004*

Text-mined interactions from Literome

Galleguillos et al., J Biol Chem 2004 : Interestingly, PIASgamma induced repression of Nurr1 activity does not require the two sumoylation sites, because each mutant is repressed as efficiently as the wild type Nurr1
Arredondo et al., PloS one 2013 : PIAS? , a SUMO-E3 ligase, represses Nurr1 transcriptional activity ... On the other hand, PIAS? fully represses Nurr1 transactivation through a direct interaction, independently of its E3-ligase activity