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DDR1 — MAPK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → DDR1 (increases, DDR1 Activity, MAPK1 Activity)
  Evidence: We further demonstrated that DDR1 activated the MAPK cascade in a Ras-dependent manner. When DDR1 and either a DN mutant form of Ras (N17Ras) or Raf1 (DN-Raf-Flag), a direct downstream effector of Ras, were transiently transfected into 293T cells stimulated with collagen IV, activation levels of ERK were substantially decreased (Figure 4B). These findings demonstrated that DDR1 activates MAPK through Ras and Raf, as has been demonstrated for p53-induced MAPK activation (Lee et al., 2000).

Text-mined interactions from Literome

Matsuyama et al., J Immunol 2003 (MAP Kinase Signaling System) : Activation of DDR1b on differentiated DDR1b overexpressing THP-1 cells or DDR1 on mature DCs induced the formation of TNFR associated factor 6 (TRAF6)/TGF-beta activated kinase 1 binding protein 1beta/p38alpha MAPK complex and p38alpha autophosphorylation ... Transfection of differentiated DDR1b overexpressing THP-1 cells with dominant negative TRAF6 completely abrogated DDR1b mediated p38 MAPK phosphorylation, indicating a critical role of TRAF6 in DDR1b mediated p38 MAPK activation
Matsuyama et al., Am J Respir Cell Mol Biol 2005 (Sarcoidosis, Pulmonary) : Activation of DDR1 induced monocyte chemoattractant protein-1 ( MCP-1 ) and matrix metalloproteinase-9 (MMP-9) production in a p38 mitogen activated protein kinase dependent manner from CD14 positive BALF cells of patients with deteriorated sarcoidosis
Ruiz et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Furthermore, activation of DDR2, JAK2, and ERK1/2 MAPK signaling pathways was essential for collagen I-induced DDR1 and matrix metalloproteinase 10 expression