Gene interactions and pathways from curated databases and text-mining

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CBL — LCK

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

van Leeuwen et al., Mol Cell Biol 1999 (Cell Transformation, Neoplastic) : The requirement for Fyn, Lck , and ZAP-70 is not due to tyrosine phosphorylation of 70Z Cbl , as mutation of all tyrosines in, or deletion of, the C-terminal region of 70Z Cbl ( amino acids 655 to 906 ) blocks 70Z Cbl tyrosine phosphorylation but enhances 70Z Cbl mediated NFAT activation
Rao et al., Proc Natl Acad Sci U S A 2002 : Negative regulation of Lck by Cbl ubiquitin ligase ... Coexpression in 293T cells demonstrated that Lck kinase activity and Cbl ubiquitin ligase activity were essential for Lck ubiquitination and negative regulation of Lck dependent serum response element-luciferase reporter activity ... The Lck SH3 domain was pivotal for Cbl-Lck association and Cbl mediated Lck degradation, with a smaller role for interactions mediated by the Cbl tyrosine kinase binding domain ... Our results demonstrate a direct, ubiquitination dependent, negative regulatory role of Cbl for Lck in T cells, independent of Cbl mediated regulation of ZAP-70
Yang et al., Virology 2005 (HIV Infections) : Furthermore, Lck is required for Nef mediated c-Cbl tyrosine phosphorylation