Gene interactions and pathways from curated databases and text-mining

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IFNG — NOD2

Text-mined interactions from Literome

Rosenstiel et al., Gastroenterology 2003 : TNF-alpha and IFN-gamma regulate the expression of the NOD2 ( CARD15 ) gene in human intestinal epithelial cells
Tötemeyer et al., J Immunol 2006 : IFN-gamma increases NOD-2 expression and dissociates this protein from the actin cytoskeleton within the cell
Farkas et al., Scand J Immunol 2008 : Our study provides evidence that NOD2 , toll-like receptor 4 (TLR4) and the adapter protein receptor interacting protein 2 (RIP2) are induced by tumor-necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in the bronchial epithelial cell line BEAS-2B
Rosenzweig et al., Invest Ophthalmol Vis Sci 2009 (Disease Models, Animal...) : NOD2 activation resulted in the production of IFN-gamma within the eye
van Hoffen et al., Int Arch Allergy Immunol 2010 : Apically added LGG, TLR2 and NOD2 ligands, but not Bb, enhanced IFN-gamma , IL-12 and/or TNF-alpha secretion
Hosokawa et al., J Periodontal Res 2010 (Chronic Periodontitis...) : TNF-alpha and IFN-gamma increased NOD2 expression in HGFs
de Jong et al., PLoS Pathog 2012 (Salmonella Infections...) : The interaction of Salmonella pathogen associated molecular patterns ( PAMPs ) with Toll-like receptors ( TLRs ) and NOD-like receptors ( NLRs ) leads to inflammasome formation, activation, and recruitment of neutrophils and macrophages and the production of pro-inflammatory cytokines, most notably interleukin (IL)-6, IL-1ß, tumor necrosis factor (TNF)-a, and interferon-gamma (IFN)-?
Swain et al., J Biosci 2013 (Bacterial Infections) : In response to both Gram positive and Gram negative bacterial infections, NOD1 and NOD2 receptors signalling were activated and IL-1 beta, IL-8 and IFN- gamma were induced