◀ Back to IFNG

IFNG — MBP

Text-mined interactions from Literome

Fujimoto et al., J Neuroimmunol 1999 (Disease Models, Animal...) : Ibudilast mildly suppressed MBP induced proliferation of T cells in regional lymph nodes, the secretion of interferon-gamma from T cells activated by MBP in CFA, and the secretion of tumor necrosis factor-alpha from macrophages
Hollifield et al., Autoimmunity 2003 (Multiple Sclerosis) : In contrast, MS patients in remission produced significantly less spontaneous and MBP induced TNF-alpha, spontaneous, PHA- and MBP induced IL-1beta and PHA induced IFN-gamma together with increased production of biologically active TGF-beta1
Moldovan et al., J Neuroimmunol 2003 (Chronic Disease...) : MS patients showed significantly higher MBP induced IFNgamma responses and PLP induced IL-10 responses compared with healthy controls
Karpus et al., Eur J Immunol 1992 (Encephalomyelitis, Autoimmune, Experimental) : CD4+ Ts do not proliferate or secrete IFN-gamma , IL-2, or IL-4 in response to myelin basic protein , nor do CD4+ Ts proliferate or secrete IL-2 when co-cultured with irradiated EAE effector cells
Lopez et al., J Interferon Cytokine Res 2003 : IFN-gamma ( 100 U/ml ) and TNF-alpha ( 1000 U/ml ) or IL-5 ( 200 pM ) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes
Cai et al., Cell Immunol 2004 : PD-1 ligand blockade modestly enhanced the percentage of responding T cells and production of IFN-gamma in a primary response to myelin basic protein (MBP) in normal donors
Chew et al., Glia 2005 : In addition to changes in cell proliferation and differentiation, IFN-gamma attenuated myelin basic protein (MBP) expression significantly, which was associated with decreased expression of both MBP and Sox10 RNAs
Whitacre et al., J Immunol 1991 (Encephalomyelitis, Autoimmune, Experimental) : Thus, because lymphocytes from MBP fed rats neither proliferate nor secrete IL-2 or IFN-gamma in response to MBP and we can find no compelling evidence for the role of suppressor cells, we propose that the oral administration of MBP results in a state of clonal anergy
Tavares et al., Mem Inst Oswaldo Cruz 2006 (Tuberculosis, Pulmonary) : Cell proliferation and interferon-gamma response to recombinant MBP-3 , NarL, MT-10.3, and 16 kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients
Wolf et al., J Neuroimmunol 2007 (Encephalomyelitis, Autoimmune, Experimental) : Spleen cells proliferated and secreted IFN-gamma in response to MBP ( 68-86 ), and secreted IL-6 and IL-12p40 in response to CpG-ODN and LPS
Menon et al., Neurosci Res 2007 (Disease Models, Animal...) : Additionally, the myelin from GMF-KO mice showed difference in distribution of myelin oligodendrocyte glycoprotein ( MOG ) and beta-tubulin in a sucrose density gradient myelin-axolemmal fractions compared to WT. Taken together, our data suggests a role for GMF in the biochemical organization of myelin and thereby its effect on MBP degradation induced by RmAb and IFN-gamma
Hedegaard et al., Immunology 2008 (Multiple Sclerosis, Relapsing-Remitting) : The MBP induced a dose dependent release of interferon-gamma (IFN-gamma) , tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient derived MNCs ... A strong correlation was found between the MBP induced CD4+ T-cell proliferation and production of IL-17, IFN-gamma , IL-5 and IL-4 ( P < 0.0001 to P < 0.01 ) within the patient group, and the production of IL-17 and IL-5 correlated with the number of active plaques on magnetic resonance images ( P=0.04 and P=0.007 )
Mann et al., Journal of neuroinflammation 2008 : Corticosterone, dihydrocorticosterone and, most prominently dexamethasone, counteracted the deleterious effects of IFN-gamma and TNF-alpha on cell survival, A2B5 immunostaining and expression of myelin basic protein
Katsara et al., Immunology 2009 (Encephalomyelitis, Autoimmune, Experimental...) : It was of interest that [ R ( 91 ), A ( 96 ) ] MBP ( 87-99 ) conjugated to reduced mannan induced 70 % less IFN-gamma compared with the native MBP ( 87-99 ) peptide
Volovitz et al., J Autoimmun 2010 (Encephalomyelitis, Autoimmune, Experimental...) : Splenocytes in the control groups secreted IFNgamma in response to MBP and showed high numbers of IFNgamma secreting CD4 and CD8 cells in their spinal cords at the disease peak
Weber et al., Proc Natl Acad Sci U S A 1993 (Cell Transformation, Viral) : Antigen-specific recognition and signal transduction by the TCR were demonstrated by myelin-basic-protein induced HLA-DR restricted secretion of interferon gamma and lymphotoxin and by myelin-basic-protein-specific proliferation
Link et al., J Neuroimmunol 1994 (Multiple Sclerosis...) : There were elevated levels of cells that in response to MBP and PLP expressed IFN-gamma , IL-4 and TGF-beta mRNA in blood and further enriched in CSF in both ON and MS, compared to patients with other neurological diseases
Link et al., Ann Neurol 1994 (Multiple Sclerosis...) : There are mononuclear cells in blood and cerebrospinal fluid of patients with MS that produce interferon-gamma and interleukin-4 in response to myelin basic protein (MBP) and proteolipid protein (PLP)
Link et al., Neurology 1994 (Multiple Sclerosis...) : High numbers of IFN-gamma and IL-4 mRNA expressing cells in response to MBP and PLP were detected in patients with untreated MS, and to AChR in MG ... The levels of IFN-gamma and IL-4 mRNA positive cells in MS after culture in the presence of AChR, and in MG after culture in the presence of MBP or PLP, did not differ from those detected after culture without antigen
Stepaniak et al., J Neurosci Res 1996 (Encephalomyelitis, Autoimmune, Experimental) : Stimulation of cells from MBP73-84 : 1028 coimmunized protected rats proliferate and secrete interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) in vitro in response to MBP73-84
Ruuls et al., J Immunol 1996 (Body Weight...) : Accordingly, isolation of mononuclear cells from spinal cord tissue of successfully treated EAE rats revealed a reduction of approximately 95 % in the number of cells that produce IFN-gamma in response to the encephalitogenic peptide MBP63-88
Li et al., Immunology 1998 (Encephalomyelitis, Autoimmune, Experimental) : Rats tolerized with both doses of gp-MBP had also abrogated MBP induced IFN-gamma mRNA expression in popliteal and inguinal lymph node mononuclear cells compared with rats receiving phosphate buffered saline nasally
Rowell et al., J Immunol 1999 (Alphavirus Infections...) : CNS lymphocytes from both strains of mice produced IFN-gamma in response to stimulation with Sindbis virus, but not in response to myelin basic protein