We have a suspicion that you are an automated web bot software, not a real user. To keep our site fast for other users, we have slowed down this page. The slowdown will gradually disappear. If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu. Also note that all data for hgGeneGraph can be obtained through our public MySQL server and all our software source code is available and can be installed locally onto your own computer. If you are unsure how to use these resources, do not hesitate to contact us.
UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

◀ Back to IFNG

IFNG — IL34

Text-mined interactions from Literome

Lalain et al., Diabetologia 1999 (Diabetes Mellitus, Type 1) : During proliferation in response to islet cells, interleukin-10 increased 43-fold ( p < 0.01 ) but interferon-gamma increased only slightly
Filice et al., Infect Immun 1999 (Cytomegalovirus Infections...) : As pulmonary inflammation developed, levels of cytokine mRNAs for gamma interferon ( IFN-gamma ), interleukin-2 (IL-2), IL-4, and IL-10 increased in bronchoalveolar lavage (BAL) cells or lung tissue, and the level of IFN-gamma protein increased in BAL fluid
Sugaya et al., J Invest Dermatol 1999 : Interleukin-18 or interleukin-12 alone did not induce interferon-gamma production by dendritic epidermal T cells ... Thus, this study suggests that interleukin-18 and interleukin-12 produced by keratinocytes and Langerhans cells regulate interferon-gamma production by dendritic epidermal T cells and thus may play important parts in the regulation of immune responses in skin associated lymphoid tissues
Elhofy et al., Infect Immun 1999 (Salmonella Infections, Animal) : It has recently been suggested that, interleukin-18 (IL-18), in addition to IL-12, contributes to the induction of IFN-gamma following infection
Dybing et al., Infect Immun 1999 (Salmonella Infections, Animal) : As such, several different cytokines including, interleukin-12 (IL-12) and IL-18, can induce IFN-gamma
Francis et al., Immunology 2000 (Arthritis, Experimental...) : Peptide inhalation induces the production of Th1-type cytokines ( interferon-gamma ) whereas intraperitoneal immunization leads to the production of Th2-type cytokines ( interleukin-4, interleukin-5 and interleukin-10 ) by splenic T cells upon stimulation with peptide
Koh et al., J Clin Immunol 2001 (Asthma...) : As a correlate, interleukin-4 (IL-4) production significantly decreased and interferon-gamma (IFN-gamma) slightly increased , resulting in a markedly decreased ratio of IL-4-IFN-gamma in OVA presensitized rats with BCG infection
Kitagawa et al., J Rheumatol 2001 (Arthritis, Rheumatoid) : Interferon-gamma enhances interleukin 12 production in rheumatoid synovial cells via CD40-CD154 dependent and independent pathways
Sutherland et al., Immunol Rev 2001 : Although ULBPs alone activate multiple signaling pathways and induce modest cytokine production, ULBPs synergize strongly with interleukin-12 for production of interferon-gamma by NK cells
Puliti et al., Arthritis Rheum 2002 (Arthritis, Infectious...) : The beneficial effect of interleukin-12 on arthritis induced by group B streptococci is mediated by interferon-gamma and interleukin-10 production
Malmgaard et al., J Gen Virol 2003 (Herpes Simplex) : Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2
Tomoda et al., Biochim Biophys Acta 1992 (Leukemia, Monocytic, Acute) : Inhibition of interferon-gamma- and phorbol ester induced HLA-DR and interleukin-1 production by the expression of a transfected poly ( ADP-ribose ) synthetase gene in human leukemia THP-1 cells
Imanishi et al., Hepatogastroenterology 2003 (Carcinoma, Hepatocellular...) : We evaluated interleukin-12 induced interferon-gamma production as one of the immunological markers of patients with chronic liver diseases ... The level of interleukin-12 induced interferon-gamma production by peripheral blood mononuclear cells in the patients with hepatocellular carcinoma was significantly lower than that in the patients with liver cirrhosis which is thought to be a premalignant state
Murray et al., Infect Immun 2003 (Leishmaniasis, Visceral) : Optimal killing triggered by both anti-CD40 and anti-CTLA-4 required endogenous IFN-gamma and involved interleukin 12
dos Santos et al., Vet Immunol Immunopathol 2004 (Dog Diseases...) : Recombinant single-chain canine interleukin 12 induces interferon gamma mRNA expression in peripheral blood mononuclear cells of dogs with visceral leishmaniasis
Ethuin et al., Lab Invest 2004 : Human neutrophils produce interferon gamma upon stimulation by interleukin-12
Loughlin et al., Immunology 1992 : Regulation of Fc receptor and major histocompatibility complex antigen expression on isolated rat microglia by tumour necrosis factor, interleukin-1 and lipopolysaccharide : effects on interferon-gamma induced activation
Fernández-Lago et al., J Med Microbiol 2005 (Brucellosis) : Following infection, interleukin-18 (IL-18) may contribute , in association with IL-12, to optimal IFN-gamma production
Ellermann-Eriksen et al., Virology journal 2005 (Herpes Simplex) : In the next wave, interleukin (IL)-12 together with the above and other cytokines induce production of IFN-gamma in mainly NK cells
Wood et al., Eur J Pediatr 2005 (Hypersensitivity) : Defects in interferon-gamma receptor/interleukin-12 receptor responses are not sufficient to cause clinical allergic disease
Rezende et al., Int Endod J 2005 : The cellular viability and the production of tumour necrosis factor-alpha, interleukin (IL)-12 and IL-10 in response to stimulation with interferon-gamma and Fusobacterium nucleatum or Peptostreptococcus anaerobius were evaluated
Kriegel et al., Immunology 2006 : Interleukin-4 supports interleukin-12 induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cells
Al-Attiyah et al., Clin Exp Immunol 2006 (Tuberculosis) : Among the cytokines studied, interleukin (IL)-10 and IL-12 were not detected at all, whereas low levels of interferon (IFN)-gamma after 96 h ( 0.4 IU/ml ) and tumour necrosis factor (TNF)-alpha after 48 ( 135 pg/ml ) and 96 h ( 47 pg/ml ) of culture were detected in the supernatants of whole blood infected with M. tuberculosis
Price et al., Immunology 2007 : Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of interferon-gamma in response to stimulation with interleukin-12 and -18
Ghiringhelli et al., Immunol Rev 2006 (Disease Progression...) : This review summarizes the findings showing that Tregs suppress NK cell effector functions in vitro and in vivo, i.e. homeostatic proliferation, cytotoxicity, and interleukin-12 mediated IFN-gamma production
Tsuda et al., Cancer Res 2007 (Ovarian Neoplasms) : RNAs in ISMMC stimulate immature dendritic cells to secrete interleukin 12 and induce IFN-gamma in peripheral blood mononuclear cells
Ebert et al., Immunology 2008 : Massive interleukin-12 induced interferon-gamma production by interleukin-15 stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor
Lonial et al., Exp Hematol 2008 : The immunostimulatory effect of DC1 required DC-to-T-cell contact, and induced interleukin-12 secretion, while DC2 cells induced interferon-gamma secretion
Kubera et al., J Pharmacol Sci 2008 (Cocaine-Related Disorders...) : Cocaine self administered for 18 days induced a significant increase in spleen weight, plasma corticosterone levels, interleukin (IL)-10 , and tumor necrosis factor-alpha production, while concanavalin A-stimulated proliferation responses of peripheral blood T-lymphocytes and interferon-gamma production by splenic lymphocytes were not altered
Campos Alberto et al., Immunology 2009 : Differential effects of tumour necrosis factor-alpha and interleukin-12 on isopentenyl pyrophosphate stimulated interferon-gamma production by cord blood Vgamma9 T cells
Vesosky et al., Infect Immun 2009 (Tuberculosis) : In addition, M. tuberculosis induced IFN-gamma production by CD8 T cells isolated from naïve old mice was major histocompatibility complex class I independent but was dependent on interleukin-12p70 , confirming an innate role of CD8 T cells during M. tuberculosis infection
Bill et al., Mol Cancer Ther 2009 (Melanoma) : Finally, stimulation of natural killer ( NK ) cells with curcumin reduced the level of interleukin-12 induced IFN-gamma secretion, and production of granzyme b or IFN-gamma upon coculture with A375 melanoma cells or NK-sensitive K562 cells as targets
Armstrong-James et al., J Infect Dis 2009 (Pulmonary Aspergillosis) : Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis
Beldi et al., Hepatology 2010 (Reperfusion Injury) : Specifically, ATPgammaS ( a nonhydrolyzable ATP analog ) inhibits secretion of interferon gamma by NK cells in response to interleukin-12 and interleukin-18, providing a mechanistic link between CD39 deletion and altered cytokine secretion
Reiner et al., J Clin Invest 1990 (Leishmaniasis, Visceral) : Interferon-gamma prevents parasite induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1
Xie et al., Int J Oncol 1993 : L929 parental cells and L929 cells selected for resistance to tumor necrosis factor ( TNF-alpha ) were incubated in vitro with various concentrations of TNF-alpha, interleukin-1 , and lipopolysaccharide (LPS) in the presence or absence of mouse interferon-gamma (IFN-gamma)
Miossec et al., J Immunol 1986 : Immune interferon enhances the production of interleukin 1 by human endothelial cells stimulated with lipopolysaccharide
Gerrard et al., J Immunol 1987 : Differential effects of interferon-alpha and interferon-gamma on interleukin 1 secretion by monocytes
Haq et al., Immunobiology 1988 : Failure of hydrocortisone to suppress the interferon-gamma induced augmentation of interleukin 1 secretion of aged human monocytes
Auböck et al., Arch Dermatol Res 1985 : HLA-DR expression was induced by the supernatants and human recombinant interferon-gamma ( rIFN-gamma ), whereas recombinant interferon-alpha 2, interleukin-2 and non-recombinant human interferon-beta had no such effect
Hunter et al., Eur J Immunol 1995 (Toxoplasmosis, Animal) : Transforming growth factor-beta inhibits interleukin-12 induced production of interferon-gamma by natural killer cells : a role for transforming growth factor-beta in the regulation of T cell independent resistance to Toxoplasma gondii
Ogata et al., Br J Haematol 1995 (Myelodysplastic Syndromes) : Effects of interleukin-12 on natural killer cell cytotoxicity and the production of interferon-gamma and tumour necrosis factor-alpha in patients with myelodysplastic syndromes
Nakamura et al., Infect Immun 1993 : The factor, interleukin-2 , anti-CD3 MAb, or ConA alone induced a trace of or no detectable IFN-gamma in these cells
Sanchez-Bueno et al., Biochem Biophys Res Commun 1996 (Fibrosarcoma) : Interferon-gamma dependent expression of inducible nitric oxide synthase, interleukin-12 , and interferon-gamma inducing factor in macrophages elicited by allografted tumor cells
Libraty et al., J Clin Invest 1997 (Leprosy) : Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy
Trinchieri et al., Curr Opin Hematol 1997 : If interleukin-12 and interleukin-12 induced interferon gamma are present during early T-cell expansion in response to antigen, T-helper type-1 cell generation is favored and generation of T-helper type-2 cells is inhibited
Gollob et al., Eur J Immunol 1997 : Interferon-gamma and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
Hunter et al., Eur J Immunol 1997 : Comparison of the effects of interleukin-1 alpha, interleukin-1 beta and interferon-gamma inducing factor on the production of interferon-gamma by natural killer
Gross et al., Infect Immun 1998 : Expression of iNOS, interleukin-6 , and tumor necrosis factor alpha (TNF-alpha) mRNAs was induced in both c-Brucella- and ops-Brucella infected cells and was strongly potentiated by IFN-gamma
Hayes et al., Blood 1998 (Cell Transformation, Viral) : Interferon-gamma dependent inducible expression of the human interleukin-12 p35 gene in monocytes initiates from a TATA containing promoter distinct from the CpG-rich promoter active in Epstein-Barr virus transformed lymphoblastoid cells
Baden et al., J Biol Chem 1998 : The amino-terminal domain of STAT4 ( STAT4 ( 1-124 ) ) is required for cooperative binding interactions between STAT4 dimers and activation of interferon-gamma transcription in response to interleukin-12
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta, tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Byl et al., J Interferon Cytokine Res 1998 (Acquired Immunodeficiency Syndrome) : Bacterial extract OM85-BV induces interleukin-12 dependent IFN-gamma production by human CD4+ T cells
Hodge-Dufour et al., Proc Natl Acad Sci U S A 1998 (Inflammation) : Inhibition of interferon gamma induced interleukin 12 production : a potential mechanism for the anti-inflammatory activities of tumor necrosis factor