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IFNG — IL12RB2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Zhang et al., J Immunol 1999
:
These results suggest that
IL-12R signaling
affects IFN-gamma gene transcription by at least two separate mechanisms ; IL-12R signaling without TCR signaling targets promoter regions outside of the approximately 100-bp IFN-gamma TCR-RE, and IL-12R signaling also stimulates TCR induced activity of the proximal TCR-RE
Wu et al., Eur J Immunol 2000
:
Using an antibody specific for the human IL-12Rbeta2 subunit, the
effect of
IFN-gamma , IFN-alpha, IL-12 and IL-2 on the regulation of
IL-12R expression and IL-12 responsiveness of human T and NK cells was assessed ... The presence of IFN-alpha or
IFN-gamma in cultures
enhanced IL-12Rbeta2 expression of CD4 ( + ) and CD8 ( + ) T cells ... Furthermore, the clearest
effects of IFN-alpha and
IFN-gamma on
IL-12Rbeta2 expression on T cells were seen by abrograting the inhibition induced by the presence of IL-4 in cultures ... Taken together, these data show that there is differential
regulation of
IL-12Rbeta2 expression by IFN-alpha and
IFN-gamma on human T and NK cells
Salkowski et al., J Immunol 2000
(Endotoxemia...) :
IFN-gamma induced
IL-12Rbeta2 mRNA expression was also diminished in macrophages from IRF-1-/- mice
Yamane et al., Eur J Immunol 2000
:
CD28 ligation induced not only IL-12Rbeta1 and beta2 mRNA expression, but also enhanced IFN-gammaR to mediate
up-regulation of
IL-12R by
IFN-gamma
Padigel et al., J Immunol 2001
(Leishmaniasis, Cutaneous) :
At wk 9 of infection, we
detected similar levels of IL-4,
IFN-gamma , IL-12p40, and IL-12Rbeta2 mRNA in draining lymph nodes of healing C57BL/6, CD28 ( -/- ), and CD40L ( -/- ) CD28 ( -/- ) mice, whereas CD40L ( -/- ) mice had increased mRNA levels for IL-4 but reduced levels for IFN-gamma, IL-12p40, and
IL-12Rbeta2
Kuroda et al., J Immunol 2002
:
IFN-gamma produced by activated macrophages
induced IL-12R mRNA expression in T cells and macrophages themselves depending on their amount of IFN-gamma ; namely, macrophages from BALB/c mice induced lower expression of IL-12R
Smeltz et al., J Immunol 2002
:
These data clarify the
role of
IFN-gamma in regulation of
IL-18Ralpha/IL-12Rbeta2 during both IL-12 dependent and IL-12 independent Th1 differentiation
Morinobu et al., Proc Natl Acad Sci U S A 2002
:
The inability of STAT4 S721 to restore
IFN-gamma production was not
caused by decreased
IL-12R expression because the STAT4 S721 mutant also failed to restore IFN-gamma production in STAT4-deficient IL-12Rbeta2 transgenic cells
Okazawa et al., Am J Gastroenterol 2002
(Crohn Disease...) :
The functional activity of IL- 12 and IL-18 was assessed by the effect of recombinant IL-12 and recombinant IL-18 on
interferon-gamma production, the proliferative response, and the
induction of IL-2R,
IL-12R , and IL-18R of LPLs
Wu et al., J Neuroimmunol 2003
(Encephalomyelitis, Autoimmune, Experimental...) :
The
IL-12R beta 2 expression on Th1 cells from draining LNC was increased in the
presence of IL-12 and
IFN-gamma
Hibbert et al., J Interferon Cytokine Res 2003
:
In contrast,
IFN-gamma , which activates Stat1 but not Stat3,
induces expression of T-Bet but not
IL-12Rbeta2 in naive T cells
Li et al., J Neurol Sci 2003
:
Expression of the
IL-12R subunits, IL-12Rbeta1 and IL-12Rbeta2, is upregulated in both microglia and splenic macrophages upon
stimulation with LPS or
IFN-gamma and LPS, whereas the IL-23R subunit is upregulated only in macrophages
Xu et al., Invest Ophthalmol Vis Sci 2003
(Autoimmune Diseases...) :
The parameters measured were T-cell proliferation,
IFN-gamma production,
induction of
IL-12R expression, triggering of pathogenicity, and expression of costimulatory molecules on antigen presenting cells (APCs) during in vitro exposure to antigen
Kamiya et al., J Immunol 2004
:
In contrast, IL-27 hardly induced T-bet and subsequent
IL-12Rbeta2 expression, and synergistic
IFN-gamma production by IL-27 and IL-12 was
impaired in STAT1-deficient naive CD4+ T cells
Shin et al., J Immunol 2005
(Asthma) :
STAT4, which plays a pivotal role in Th1 immune responses, enhances
IFN-gamma transcription in
response to the interaction of IL-12 with the
IL-12R
Gagro et al., Immunology 2006
:
IL-12Rbeta2 could be
induced on a minority of B cells by the same signals, and also by
IFN-gamma alone
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA,
IL-12R , IL-2Ralpha and CD40L expression and also
inhibited IL-12- and IL-23 induced
IFN-gamma , IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Chang et al., Blood 2009
(Lymphoma) :
Reconstitution of STAT4 in patient T cells allowed recovery of IFNgamma and IL-12Rbeta2 expression, whereas ectopic expression of
IL-12Rbeta2 did not rescue STAT4 expression, and
increased IFNgamma production only to levels intermediate between control and patient samples
Schulz et al., Immunity 2009
:
We show that
interferon-gamma induced initial T-bet expression, whereas
IL-12Rbeta2 was repressed by T cell receptor ( TCR ) signaling
Kim et al., Exp Mol Med 2010
(Asthma...) :
Moreover, AHR, non-eosinophilic inflammation, and
IFN-gamma expression were
impaired in allergen challenged
IL-12Rbeta2- and STAT4-deficient mice ; however, AHR and non-eosinophilic inflammation were not impaired in allergen challenged IL-4Ralpha-deficient mice, and these phenomena were accompanied by the enhanced expression of IL-12 and IFN-gamma