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GSK3B — ILKAP
Text-mined interactions from Literome
Leung-Hagesteijn et al., EMBO J 2001
:
Catalytically active, but not mutant
ILKAP , strongly
inhibited insulin-like growth factor-1 stimulated
GSK3beta phosphorylation on Ser9, but did not affect phosphorylation of PKB on Ser473, suggesting that ILKAP selectively affects ILK mediated GSK3beta signalling
Kumar et al., Oncogene 2004
(Cell Transformation, Neoplastic) :
Silencing of endogenous
ILKAP by short interfering RNA ( siRNA )
stimulated GSK3beta phosphorylation at S9, with no effect on PKB S473 phosphorylation ... Consistent with the silencing data,
ILKAP inhibition of ILK selectively
inhibited S9 phosphorylation of
GSK3beta without affecting S473 phosphorylation of PKB