Gene interactions and pathways from curated databases and text-mining

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EGR1 — IRS1

Text-mined interactions from Literome

Solow et al., Arch Biochem Biophys 1999 (Kidney Diseases...) : These results suggest that insulin induced egr-1 expression in mouse mesangial cells is downstream of tyrosine phosphorylation of IRS-1 and activation of the MAP kinase pathway and that crosstalk between angiotensin II and insulin signaling pathways led to an inhibition of IRS-1 tyrosine phosphorylation and egr-1 expression
BrĂ¼ning et al., Mol Cell Biol 1997 : Expression of IRS-1 in IRS-1-deficient cells by retroviral gene transduction restores IGF-1 stimulated mitogenesis, PI 3-kinase activation, and c-fos and egr-1 induction in proportion to the level of reconstitution