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EGR1 — IRS1
Text-mined interactions from Literome
Solow et al., Arch Biochem Biophys 1999
(Kidney Diseases...) :
These results suggest that insulin induced
egr-1 expression in mouse mesangial cells is downstream of tyrosine phosphorylation of IRS-1 and activation of the MAP kinase pathway and that crosstalk between angiotensin II and insulin signaling pathways
led to an inhibition of
IRS-1 tyrosine phosphorylation and egr-1 expression
BrĂ¼ning et al., Mol Cell Biol 1997
:
Expression of
IRS-1 in IRS-1-deficient cells by retroviral gene transduction
restores IGF-1 stimulated mitogenesis, PI 3-kinase activation, and c-fos and
egr-1 induction in proportion to the level of reconstitution