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EGFR — PLAUR

Text-mined interactions from Literome

Liu et al., Cancer Cell 2002 (Carcinoma, Hepatocellular...) : Its activation is ligand independent and does not require high EGFR , but does require high uPAR expression
Mamoune et al., Exp Cell Res 2004 (Carcinoma...) : Gene microarray analyses have suggested that EGFR signaling via phospholipase C-gamma ( PLCgamma ) induces uPAR transcription
Monaghan-Benson et al., J Biol Chem 2006 : The effects of P25 on matrix assembly and beta1 integrin activation were inhibited by pretreatment with EGFR or Src kinase inhibitors, suggesting a role for both Src and EGFR in integrin activation by uPAR ... These data provide evidence for a novel pathway of fibronectin matrix assembly through the uPAR dependent sequential activation of Src kinase, EGFR , and beta1 integrin
Gondi et al., Clin Cancer Res 2007 (Brain Neoplasms...) : In 4910 EGFR overexpressing cells, down-regulation of uPAR and uPA induced the down-regulation of EGFR and vascular endothelial growth factor and inhibited angiogenesis in both in vitro and in vivo angiogenic assays
Abu-Ali et al., Molecular cancer 2008 (Head and Neck Neoplasms) : ACCS, ACCS-AS and NA-SCC cells were used to elucidate the relationships between uPAR down-regulation and EGFR inhibition
Monaghan-Benson et al., J Cell Sci 2008 : Caveolin-1 functions initially as a membrane adaptor or scaffold to mediate uPAR dependent activation of Src and EGFR