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CXCR4 — EGFR
Text-mined interactions from Literome
Porcile et al., Ann N Y Acad Sci 2004
(Adenocarcinoma...) :
CXCR4 activation
induces epidermal growth factor receptor transactivation in an ovarian cancer cell line
Rahimi et al., Int J Cancer 2010
(Breast Neoplasms...) :
EGFR variant
mediated invasion by enhanced
CXCR4 expression through transcriptional and post-translational mechanisms
Abhold et al., PloS one 2012
(Carcinoma, Squamous Cell...) :
Activation of
EGFR by the addition of EGF ligand or ectopic expression of EGFR in two established HNSCC cell lines ( UMSCC-22B and HN-1 )
resulted in the induction of CD44, BMI-1, Oct-4, NANOG,
CXCR4 , and SDF-1
Zhao et al., PloS one 2012
(MAP Kinase Signaling System) :
The inhibition of CXCL12 or
CXCR4 by either neutralizing antibodies or small interfering RNA ( siRNA ) could completely
block the CsA induced
EGFR phosphorylation
Weekes et al., Neoplasia (New York, N.Y.) 2012
(Pancreatic Neoplasms) :
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CXCR4 promoted intratumoral
EGFR expression in association with temsirolimus resistance ... Next,
CXCR4 promoted intratumoral
EGFR expression in association with temsirolimus resistance