Gene interactions and pathways from curated databases and text-mining

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CDH2 — SNAI2

Text-mined interactions from Literome

Sivertsen et al., Lung Cancer 2006 (Mesothelioma...) : Snail, Slug and Sip1 regulate cadherin and protease expression and mediate epithelial-mesenchymal transition in cancer
Leong et al., J Exp Med 2007 (Breast Neoplasms) : Slug was essential for Notch mediated repression of E-cadherin , which resulted in beta-catenin activation and resistance to anoikis
Saegusa et al., Am J Pathol 2009 (Carcinosarcoma...) : Moreover, Slug overexpression itself caused repression of E-cadherin , with subtle changes in cell morphology
Yang et al., Mol Cell Proteomics 2010 (Gastrointestinal Stromal Tumors...) : An increase in Slug expression by pCMV6-XL5-Slug transfection decreased E-cadherin and increased vimentin and N-cadherin
Shirley et al., Am J Pathol 2012 (Disease Progression...) : Expression of exogenous Slug in melanocytes and melanoma cells in vitro, however, suppressed E-cadherin expression, enhanced N-cadherin expression, and stimulated cell migration and invasion