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CDC7 — MCM6

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: Complex of CDC7-DBF4 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7 (protein-protein, phosphorylation)
  
• Reactome Reaction: CDC7 → MCM6 (reaction) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999, Masai et al., J Biol Chem 2000
• Reactome Reaction: CDC7 → MCM6 (indirect_complex) Kumagai et al., Mol Cell Biol 1999, Jiang et al., EMBO J 1999
• WikiPathways Cell Cycle: CDC7/DBF4 → Complex of MCM2-MCM3-MCM4-MCM5-MCM6-MCM7-MCM8-MCM9-MCM10 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MCM6 — CDC7 (direct interaction, enzymatic study) Masai et al., J Biol Chem 2000

Text-mined interactions from Literome

Kundu et al., Nucleic Acids Res 2010 : Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7 mediated phosphorylation of Mcm2-7 complex ... Remarkably, Cdc6 itself does not directly inhibit Cdc7 kinase activity towards Mcm2-4-6-7 in purified systems, rather modulates Mcm2-7 phosphorylation on chromatin context ... Taken together, we propose that Cdc6 on chromatin acts as a modulator of Cdc7 mediated phosphorylation of Mcm2-7 , and thus destabilization of Cdc6 from chromatin after licensing is a key event ensuring proper transition to the initiation of DNA replication
Hubbi et al., Science signaling 2013 : Although the interaction between Cdc6 and the MCM complex increased the association of the MCM proteins with chromatin, the binding of HIF-1a to the complex decreased phosphorylation and activation of the MCM complex by the kinase Cdc7