Gene interactions and pathways from curated databases and text-mining

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CD69 — CD8A

Text-mined interactions from Literome

Giavedoni et al., J Virol 2000 (Simian Acquired Immunodeficiency Syndrome) : CD8 ( + ) T cells increased CD69 but not CD25 expression, indicating the activation of this cellular subset in PB and LN
Heinzelmann et al., Immunopharmacology 2000 : Analysis of leukocyte subsets demonstrated that CD4 ( + ) T-cells, CD8 ( + ) T-cell, CD19 ( + ) B-cells, CD56 ( + ) natural killer ( NK ) -cells, and CD14 ( + ) monocytes increased the expression of CD69 after stimulation with LPS
Fauconnier et al., Am J Pathol 2011 (Brain Ischemia...) : Recruitment and activation of CD8 ( + ) T cells, and ICAM-1 and CD69 expression were reduced in the brain of resistant mice ; however, the pulmonary inflammation and edema associated with PbA infection were still present in the absence of functional PKC-?
Freeman et al., Proc Natl Acad Sci U S A 2012 : This study identifies several unexpected cytokine combinations that synergize to induce antigen independent IFN? production and CD69 up-regulation by CD8 ( + ) T cells in addition to cytokines that exhibit differential regulatory functions, with the ability to either enhance or inhibit T-cell IFN? production, depending on which cytokine partner is present
Lim et al., Mol Cells 1998 : However, stimulation of CD8-Igbeta can induce activation of CD69 surface expression and IL-2 gene expression equivalent to the level by CD8-Igalpha and CD8-zeta without induction of the tyrosine phosphorylation of intracellular signaling molecules