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CD4 — RAF1

Text-mined interactions from Literome

Popik et al., Mol Cell Biol 1996 : Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras independent pathway ... The association between Lck and Raf-1 was mediated by stimulation of the CD4 receptors, since it was abolished by preincubation of the virus with soluble CD4 and was not detected in CD4 negative A201 T cells ... Surprisingly, the CD4 mediated signaling, induced by the HIV-1 binding, did not result in stimulation of the Ras GTP binding activity or its association with Raf-1 , indicating that the signaling pathway generated by the HIV-1 binding is not identical to the classical Ras/Raf-1 pathway
Kirk et al., Cell Immunol 1998 : We also found that Raf-1 activation by CD3/CD4 costimulation is lower in memory cells than in naïve cells from mice of the same age