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Deng et al., Brain Res Mol Brain Res 2000 : Administration of methamphetamine caused significant increases in terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling ( TUNEL ) -positive cells, in poly ( ADP-ribose ) polymerase ( PARP ) cleavage, as well as in caspase-3 activity in the striata of C57BL/6J mice
Aljandali et al., J Lab Clin Med 2001 : To determine whether asbestos causes apoptosis in AECs, we exposed WI-26 ( human type I-like cells ), A549 ( human type II-like cells ), and rat alveolar type II cells to amosite asbestos and assessed apoptosis by terminal deoxynucleotidyl transferase mediated deoxyuridine-5'-triphosphate-biotin nick end labeling ( TUNEL ) staining, nuclear morphology, annexin V staining, DNA nucleosome formation, and caspase 3 activation
Heczko et al., Infect Immun 2001 (Escherichia coli Infections) : Simultaneously, ileal apoptosis was assessed by using terminal deoxynucleotidyltransferase mediated dUTP-biotin nick end labeling ( TUNEL ) and caspase 3 assays and by apoptotic cell counts based on morphology ( hematoxylin-and-eosin staining )
Sanchez-Esteban et al., Am J Physiol Lung Cell Mol Physiol 2002 : At this same gestational age, stretch induced apoptosis by two- to threefold over controls, assayed by DNA flow cytometry, terminal deoxynucleotidyl transferase mediated dUTP-FITC nick-end labeling, and caspase-3 activation
Bartunek et al., J Am Coll Cardiol 2002 (Cardiomyopathy, Dilated) : Terminal deoxynucleotidyltransferase mediated biotin-dUTP nick-end labeling ( TUNEL ) or cleaved caspase-3 and cleaved PARP could not be detected
Cottrell et al., Neuropathol Appl Neurobiol 2002 (Alzheimer Disease) : In addition, we also directly colocalized these mitochondrial-enzyme deficient neurones using terminal deoxynucleotidyl transferase mediated dUTP nick end labelling and cleaved caspase-3
Holzknecht et al., Circ Res 2002 (Acute Disease...) : Apoptosis, assayed by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ), expression of activated caspase-3 , and proapoptotic genes Bax and Bcl-x ( L ), was not detected until acute vascular rejection was well advanced, and even then, apoptosis was largely confined to myocytes
Whitehead et al., Mol Cancer Ther 2003 (Carcinoma, Non-Small-Cell Lung...) : Orthotopic A549 rat lung tissue sections from drug treated rats and A549 cell culture responses to exisulind and docetaxel were compared using multiple apoptosis and proliferation analyses [ i.e., terminal deoxynucleotidyl transferase mediated nick end labeling, active caspase 3, the caspase cleavage products cytokeratin 18 and p85 poly ( ADP-ribose ) polymerase, and Ki-67 ]
Kang et al., Am J Pathol 2003 (Myocardial Infarction...) : This inhibition correlated with the antiapoptotic effect of MT, as determined by a terminal deoxynucleotidyl transferase mediated deoxyuridine 5-triphosphate nick-end labeling assay, mitochondrial cytochrome c release and caspase-3 activation
Jones et al., J Virol 2003 (Necrosis) : HSV-2 induced loss of DC viability was more rapid than that induced by HSV-1 and was due, in part, to apoptosis, as shown by TEM, caspase-3 activation , and terminal deoxynucleotidyl transferase mediated dCTP biotin nick end labeling
Rudkowski et al., Am J Physiol Lung Cell Mol Physiol 2004 (Acute Disease...) : Apoptosis was evaluated using DNA fragmentation, terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling staining, and caspase activation
McCully et al., Am J Physiol Heart Circ Physiol 2004 (Myocardial Infarction...) : Myocardial injury was determined by triphenyltetrazolium chloride ( TTC ) staining, terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling ( TUNEL ), bax, bcl2, poly ( ADP ) ribose polymerase ( PARP ) cleavage, caspase-3 , -8, and -9 cleavage and activity, Fas ligand (FasL), and Fas activated death domain (FADD)
Wu et al., Circulation 2004 : Hypoxia results in an increase of apoptosis in bovine aortic endothelial cells ( BAECs ), as determined by terminal deoxynucleotidyl transferase mediated dUTP biotin nick-end labeling ( TUNEL ) analysis and caspase-3 activity
Duboc et al., Ann Neurol 2004 : Ultrastructural examination of the retina confirmed the presence of major photoreceptor damages, which were further supported by terminal deoxynucleotidyltransferase mediated dUTP nick end labeling ( TUNEL ) and caspase-3 activation both indicative of photoreceptor apoptosis
Luijerink et al., Kidney Int 2004 (Disease Models, Animal...) : Challenge of Fah ( -/- ) mice on NTBC with HGA led to massive death of renal proximal tubular cells, with positive terminal deoxynucleotidyl transferase mediated deoxyuridine diphosphate ( dUDP ) nick-end labeling ( TUNEL ) and DNA fragmentation assays, but hardly any cleavage of caspase-9 and caspase-3
Kytö et al., Am J Cardiol 2004 (Myocarditis) : Apoptotic DNA fragmentation ( terminal transferase mediated DNA nick end labeling ) and activation of caspase-3 ( immunohistochemistry ) were detected
Ray et al., Clin Immunol 2004 (Multiple Myeloma) : The PPARgamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 ( 15d-PGJ2 ) and ciglitazone, induced multiple myeloma cell apoptosis as determined by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling ( TUNEL ) assay, loss of mitochondrial membrane potential, and caspase activation
Kon et al., Hepatology 2004 (Necrosis) : Apoptosis indicated by nuclear changes, terminal deoxynucleotidyl transferase mediated dUTP nick end labeling, and caspase-3 activation also increased after acetaminophen administration
Tanaka et al., J Thorac Cardiovasc Surg 2005 (Coronary Disease...) : To analyze ischemia-reperfusion injury, grafts were procured at 4 hours after transplantation and analyzed for superoxide generation ; myeloperoxidase activity ; tumor necrosis factor alpha, interleukin 1beta, and monocyte/macrophage chemoattractant protein 1 production ; and cardiomyocyte apoptosis by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling and caspase 2, 3, 8, and 9 activity
Argenti et al., J Neurosci 2005 : Finally, REN enhances caspase-3 activation and terminal deoxynucleotidyl transferase mediated biotinylated UTP nick end labeling apoptotic GCP numbers ; therefore, the pattern of REN expression, its activity, and its antagonism on the Hedgehog pathway suggest that this gene may represent a restraint of Shh signaling at the outer to inner EGL GCP transitions
Villanueva et al., Am J Physiol Regul Integr Comp Physiol 2006 (Acute Kidney Injury...) : Ischemic damage was assessed by conventional morphology, serum creatinine, and the apoptotic markers terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling ( TUNEL ) and caspase 3
Ramos et al., Am J Physiol Lung Cell Mol Physiol 2006 : Growth rate was evaluated by WST-1 colorimetric assay, DNA synthesis by [ ( 3 ) H ] thymidine incorporation, and apoptosis by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) and cleaved caspase 3
Brunt et al., Arterioscler Thromb Vasc Biol 2006 : OS was determined by CM-H2DCFDA fluorescence, and apoptosis was assessed by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ), caspase-3 activity, and Bcl-2/Bad levels
Cai et al., J Am Coll Cardiol 2006 (Cardiomyopathies...) : On days 7, 14, and 21 after STZ treatment, cardiac apoptosis was examined by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) assay and caspase-3 activation
Suzuki et al., J Am Coll Cardiol 2007 : Cardiac apoptosis was measured by terminal deoxy-nucleotidyl transferase mediated dUTP nick end labeling staining and caspase-3 activity after in vitro and in vivo exposure to LPS
Shacka et al., J Neurosci 2007 (Disease Models, Animal...) : Cell death and apoptosis were evidenced by increases in terminal deoxynucleotidyl transferase mediated biotinylated UTP nick end labeling ( TUNEL ) reactivity and activation of caspase-3 , respectively
Caruso et al., Endocrinology 2007 (Inflammation) : In astrocytes, LPS/IFN-gamma treatment reduced cell viability, increased the number of terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling positive cells and activated caspase-3
Wei et al., Spine J 2008 : Cellular apoptosis was evaluated by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay and caspase-3 activity
Muyllaert et al., Am J Pathol 2008 (Atrophy...) : Degenerating neurons did not stain for terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling or activated caspase-3 but were marked by FluoroJadeB in early stages
Liu et al., Am J Physiol Heart Circ Physiol 2008 : Cell death was measured by terminal deoxynucleotidyl transferase dUTP mediated nick-end labeling, annexin V-fluorescein isothiocyanate, activation of caspase-9 and -3, and cleavage of poly ( ADP-ribose ) polymerase ( PARP )
Onoue et al., FEBS J 2008 : There appeared to be significant apoptotic cell death after 2 h of treatment with streptozotocin at 10 mM, as demonstrated by terminal deoxynucleotidyl transferase mediated dUTP nick end labeling staining and 2.6-fold activation of cellular caspase-3 , an apoptotic enzyme
Schmidt et al., Am J Physiol Cell Physiol 2009 (Acantholysis...) : In skin lesions from two PV patients, terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) positivity, but not cleaved caspase-3 , was detected in single keratinocytes in some lesions but was completely absent in other lesions from the same patients
Saulnier Sholler et al., J Pediatr Hematol Oncol 2009 (Neuroblastoma) : Cell morphology, terminal deoxynucleotidyltransferase mediated dUTP nick end labeling assay, and caspase-3 activation indicate that cell death was primarily due to apoptosis
Uchida et al., Liver Transpl 2009 (Reperfusion Injury) : The expression of pro-inflammatory cytokines ( tumor necrosis factor alpha and interleukin 6 ) and chemokines [ chemokine ( C-X-C motif ) ligand 1 ( CXCL-1 ), CXCL-2, and CXCL-10 ] was significantly reduced in the NEI treatment group, along with diminished apoptosis, according to terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling staining and caspase-3 activity
Selzner et al., Liver Transpl 2009 (Disease Models, Animal...) : Liver injury ( enzyme release ), apoptosis ( terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate-digoxigenin nick-end labeling staining, cytochrome C release, and caspase activation ), and necrosis ( hematoxylin and eosin staining ) were assessed
YU et al., Nan Fang Yi Ke Da Xue Xue Bao 2011 : The levels of cell apoptosis and proliferation in early mouse embryos in different developmental status ( morphologically normal embryos, arrested embryos and fragmented embryos ) were analyzed with terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ), caspase in situ fluorescence and Bcl-2 immunofluorescence, and immunofluorescent detection of proliferating cell nuclear antigen ( PCNA )
Liu et al., Anesthesiology 2012 (Pain) : Neuroapoptosis was measured by cleaved caspase-3 expression and terminal deoxynucleotidyl-transferase mediated 2'-deoxyuridine 5'-triphosphate nick end labeling staining ... Ketamine induced a significant increase in cleaved caspase-3 expression and terminal deoxynucleotidyl-transferase mediated 2'-deoxyuridine 5'-triphosphate nick end labeling staining with increases in cyclin D1 levels
Zhao et al., Toxicol Appl Pharmacol 2012 (Carcinoma, Non-Small-Cell Lung...) : Molecular analysis indicated that the high efficacy of SL-01 was associated with its ability to induce apoptosis as evidenced by increase of terminal deoxynucleotidyl transferase mediated dUTP nick end labeling ( TUNEL ) staining cells, activation of caspase-9 , caspase-3 and cleaved poly ADP-ribose polymerase ( PARP ) in tumor tissues
Miao et al., Curr Eye Res 2013 (Disease Models, Animal...) : Results : We found that chronic alcohol consumption significantly increased retinal ganglion cell ( RGC ) apoptosis in the retina of WT mice, but not AT1-KO mice, detected by terminal deoxynucleotidyl-transferase mediated dUTP-nick-end labeling staining and caspase 3 activation, along with an up-regulation of AT1 expression in RGC