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ANGPT2 — ANXA6

Text-mined interactions from Literome

Hafizi et al., Am J Physiol Heart Circ Physiol 2004 : In conclusion, we have shown that ANG II activates components of the rapamycin-sensitive mTOR signaling pathway in human cSMCs and involves activation of phosphatidylinositol 3-kinase, p70 ( S6k ), and eukaryotic initiation factor-4E, which leads to activation of protein synthesis
Kim et al., Am J Physiol Endocrinol Metab 2012 : From these results, we conclude that activation of mTOR/p70S6K by ANG II in vascular endothelium may contribute to impairment of insulin stimulated vasodilation through phosphorylation of IRS-1 at Ser ( 636/639 )
Sadoshima et al., Circ Res 1995 (Cardiomegaly) : Using cultured neonatal rat ventricular myocytes, we examined whether Ang II activates p70S6K and investigated the effect of rapamycin, a potent yet indirect inhibitor of p70S6K, on the Ang II-induced hypertrophic response
Takano et al., FEBS Lett 1996 (Cardiomegaly) : In the present study, we have examined whether Ang II activates p70 S6 kinase (p70S6K) , which has been reported to phosphorylate S6 protein ... Ang II activated p70S6K through AT1 receptor
Graves et al., J Biol Chem 1997 : These results show that in GN4 cells, Ang II selectively activates p70 ( S6K ) through effects on calcium, p90 ( RSK ) through effects on protein kinase C ... The activation of p70 ( S6K ) by calcium stimuli or Ang II was independent of calmodulin but correlated well with the activation of the recently identified, nonreceptor calcium dependent tyrosine kinase ( CADTK ) /PYK-2 ... Both calcium- and Ang II-dependent activation of p70 ( S6K ) were attenuated by the tyrosine kinase inhibitor genistein, and activation of p70 ( S6K ) was higher in GN4 than WB cells, correlating with the increased expression and activation of CADTK/PYK-2 in GN4 cells