Gene interactions and pathways from curated databases and text-mining

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INSR — TYR

Text-mined interactions from Literome

Koren et al., Best Pract Res Clin Endocrinol Metab 2007 (Diabetes Mellitus, Type 2...) : The association of insulin resistance with these disorders and the knowledge that insulin receptor signaling is mediated by tyrosine (Tyr) phosphorylation have generated great interest in the regulation of the balance between Tyr phosphorylation and dephosphorylation
Heller et al., J Biol Chem 2012 : Surprisingly, IRS-1 phosphorylation was not diminished in Y325F L-cell mutants suggesting Tyr-325 was not required for the robust insulin receptor substrate response
Sawka-Verhelle et al., J Biol Chem 1997 : Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor