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INSR — NAMPT
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
INSR
→
Complex of INSR-NAMPT
(directlyIncreases, INSR/NAMPT Activity)
Evidence: expression in plasma increases during the development of obesity;exerted insulin mimetic effects in cultured cells; binds to and activates the insulin receptor[visfatin]
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OpenBEL Selventa BEL large corpus:
INSR
→
Complex of INSR-NAMPT
(directlyIncreases, INSR/NAMPT Activity)
Evidence: It was previously identified as pre-B cell colony-enhancing factor (PBEF), a 52 000 mol. wt cytokine expressed in lymphocytes, and importantly it appears to be an insulin mimetic, both binding to and activating the insulin receptor (Fukuhara et al. 2005).
-
OpenBEL Selventa BEL large corpus:
INSR
→
NAMPT
(increases, NAMPT Activity)
Evidence: It was previously identified as pre-B cell colony-enhancing factor (PBEF), a 52 000 mol. wt cytokine expressed in lymphocytes, and importantly it appears to be an insulin mimetic, both binding to and activating the insulin receptor (Fukuhara et al. 2005).
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Fukuhara et al., Science 2005
(Diabetes Mellitus, Type 2...) :
Surprisingly,
visfatin binds to and
activates the
insulin receptor
Brown et al., J Mol Endocrinol 2010
(Diabetes Mellitus) :
Visfatin regulates insulin secretion,
insulin receptor signalling and mRNA expression of diabetes related genes in mouse pancreatic beta-cells ... Both
visfatin and nicotinamide mononucleotide
induced activation of both insulin receptor and extracellular signal regulated kinase ( ERK ) 1/2, with visfatin induced
insulin receptor/ERK1/2 activation being inhibited by FK866 ... We conclude that
visfatin can significantly
regulate insulin secretion,
insulin receptor phosphorylation and intracellular signalling and the expression of a number of beta-cell function associated genes in mouse beta-cells