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SOX9 — WNT6

Text-mined interactions from Literome

Dong et al., J Cell Physiol 2006 (Hypertrophy) : Wnt8c and Wnt9a strongly inhibited mRNA levels of Sox9 and type II collagen ( col2a1 ) ... Wnt8c further enhanced canonical bone morphogenetic proteins ( BMP-2 ) -induced expression of Runx2 and col10a1 while Wnt8c and Wnt9a inhibited TGF-beta induced expression of Sox9 and col2a1
Wang et al., Cancer Res 2007 (Neoplasm Recurrence, Local...) : SOX9 message and protein levels in prostate cancer cells were increased by treatment with glycogen synthase kinase 3beta inhibitor ( SB415286 ), and SOX9 was reduced when beta-catenin was down-regulated by small interfering RNA ( siRNA ), indicating that SOX9 expression in prostate cancer is regulated by Wnt/beta-catenin signaling
Topol et al., J Biol Chem 2009 : Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus ... Chondrocyte fate determination and maintenance requires Sox9 , an intrinsic transcription factor, but is inhibited by Wnt/beta-catenin signaling activated by extrinsic Wnt ligands
Kormish et al., Dev Dyn 2010 (Neoplasms) : In some contexts, Wnt signaling also regulates SOX expression resulting in feedback regulatory loops that fine-tune cellular responses to beta-catenin/TCF activity
Geetha-Loganathan et al., BMC developmental biology 2010 : To investigate the molecular nature of the inhibitory influence of the ectoderm, we ectopically expressed Wnt6, which is presently the only known Wnt expressed throughout the avian limb ectoderm, and found that Wnt6 overexpression leads to reduced expression of the early chondrogenic marker genes Sox9 and Collagen II
Bernard et al., Endocrinology 2012 : Wnt signaling in ovarian development inhibits Sf1 activation of Sox9 via the Tesco enhancer ... Ectopic activation of Wnt/ß-catenin signaling in male gonads led to a loss of Sf1 binding to the Tesco enhancer and absent Sox9 expression that we also observed in wild-type ovaries ... Moreover, ectopic Wnt/ß-catenin signaling induced the expression of the female somatic cell markers, Bmp2 and Rspo1, as a likely consequence of Sox9 loss
Wang et al., J Biol Chem 2013 (Breast Neoplasms...) : Consistently, SOX9 overexpression in BCa cell lines and transgenic SOX9 expression in breast epithelium caused increased LRP6 and TCF4 expression and Wnt/ß-catenin activation ... These results identify SOX9 mediated Wnt/ß-catenin activation as one of the molecular mechanisms underlying aberrant Wnt/ß-catenin activity in BCa, especially in the BL-BCa subgroup